3zot

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-	'''Unreleased structure'''	+	{{STRUCTURE_3zot| PDB=3zot | SCENE= }}
		+	===Structure of E.coli rhomboid protease GlpG in complex with monobactam L29 (data set 2)===
		+	{{ABSTRACT_PUBMED_23665170}}
-	The entry 3zot is ON HOLD until Paper Publication	+	==Function==
		+	[[http://www.uniprot.org/uniprot/GLPG_ECOLI GLPG_ECOLI]] Rhomboid-type serine protease that catalyzes intramembrane proteolysis.<ref>PMID:17099694</ref> <ref>PMID:16216077</ref>
-	Authors: Vinothkumar, K.R., Pierrat, O.A., Large, J.M., Freeman, M.	+	==About this Structure==
		+	[[3zot]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_bl21(de3) Escherichia coli bl21(de3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZOT OCA].
-	Description: Structure of E.coli rhomboid protease GlpG in complex with monobactam L29 (data set 2)	+	==Reference==
		+	<ref group="xtra">PMID:023665170</ref><references group="xtra"/><references/>
		+	[[Category: Rhomboid protease]]
		+	[[Category: Freeman, M.]]
		+	[[Category: Large, J M.]]
		+	[[Category: Pierrat, O A.]]
		+	[[Category: Vinothkumar, K R.]]
		+	[[Category: Acyl enzyme]]
		+	[[Category: Antibiotic]]
		+	[[Category: Beta lactam]]
		+	[[Category: Hydrolase]]
		+	[[Category: Intra-membrane protease]]

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Revision as of 13:53, 19 June 2013

Template:STRUCTURE 3zot

Contents 1 Structure of E.coli rhomboid protease GlpG in complex with monobactam L29 (data set 2) 2 Function 3 About this Structure 4 Reference

Structure of E.coli rhomboid protease GlpG in complex with monobactam L29 (data set 2)

Template:ABSTRACT PUBMED 23665170

Function

[GLPG_ECOLI] Rhomboid-type serine protease that catalyzes intramembrane proteolysis.^{[1] [2]}

About this Structure

3zot is a 1 chain structure with sequence from Escherichia coli bl21(de3). Full crystallographic information is available from OCA.

Reference

• Vinothkumar KR, Pierrat OA, Large JM, Freeman M. Structure of Rhomboid Protease in Complex with beta-Lactam Inhibitors Defines the S2' Cavity. Structure. 2013 May 7. pii: S0969-2126(13)00117-2. doi:, 10.1016/j.str.2013.03.013. PMID:23665170 doi:10.1016/j.str.2013.03.013

1. ↑ Wu Z, Yan N, Feng L, Oberstein A, Yan H, Baker RP, Gu L, Jeffrey PD, Urban S, Shi Y. Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat Struct Mol Biol. 2006 Dec;13(12):1084-91. Epub 2006 Nov 10. PMID:17099694 doi:10.1038/nsmb1179
2. ↑ Maegawa S, Ito K, Akiyama Y. Proteolytic action of GlpG, a rhomboid protease in the Escherichia coli cytoplasmic membrane. Biochemistry. 2005 Oct 18;44(41):13543-52. PMID:16216077 doi:10.1021/bi051363k