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4bea

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4bea| PDB=4bea | SCENE= }}
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===Crystal Structure of eIF4E in Complex with a Stapled Peptide Derivative===
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The entry 4bea is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>
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Authors: Quah, S.T., Lama, D., Verma, C.S., Lane, D.P., Brown, C.J.
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==About this Structure==
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[[4bea]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BEA OCA].
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Description: Crystal Structure of eIF4E in Complex with a Stapled Peptide Derivative
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Brown, C J.]]
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[[Category: Lama, D.]]
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[[Category: Lane, D P.]]
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[[Category: Quah, S T.]]
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[[Category: Verma, C S.]]
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[[Category: Translation]]

Revision as of 13:43, 11 December 2013

Template:STRUCTURE 4bea

Contents

Crystal Structure of eIF4E in Complex with a Stapled Peptide Derivative

Function

[IF4E_HUMAN] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.[1]

About this Structure

4bea is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Tomoo K, Matsushita Y, Fujisaki H, Abiko F, Shen X, Taniguchi T, Miyagawa H, Kitamura K, Miura K, Ishida T. Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods. Biochim Biophys Acta. 2005 Dec 1;1753(2):191-208. Epub 2005 Aug 24. PMID:16271312 doi:10.1016/j.bbapap.2005.07.023

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