4iia

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-	'''Unreleased structure'''	+	{{STRUCTURE_4iia| PDB=4iia | SCENE= }}
		+	===Low resolution crystal structure of the NTF2-like domain of human G3BP1===
		+	{{ABSTRACT_PUBMED_24324649}}
-	The entry 4iia is ON HOLD until Paper Publication	+	==Function==
		+	[[http://www.uniprot.org/uniprot/G3BP1_HUMAN G3BP1_HUMAN]] May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.<ref>PMID:9889278</ref> <ref>PMID:11604510</ref>
-	Authors: Vognsen, T., Moeller, I.R., Kristensen, O.	+	==About this Structure==
		+	[[4iia]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIA OCA].
-	Description: Low resolution crystal structure of the NTF2-like domain of human G3BP1	+	==Reference==
		+	<ref group="xtra">PMID:024324649</ref><references group="xtra"/><references/>
		+	[[Category: Kristensen, O.]]
		+	[[Category: Moeller, I R.]]
		+	[[Category: Vognsen, T.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Ntf2-like domain]]

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Revision as of 10:28, 18 December 2013

Template:STRUCTURE 4iia

Contents 1 Low resolution crystal structure of the NTF2-like domain of human G3BP1 2 Function 3 About this Structure 4 Reference

Low resolution crystal structure of the NTF2-like domain of human G3BP1

Template:ABSTRACT PUBMED 24324649

Function

[G3BP1_HUMAN] May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.^{[1] [2]}

About this Structure

4iia is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

• Vognsen T, Moller IR, Kristensen O. Crystal Structures of the Human G3BP1 NTF2-Like Domain Visualize FxFG Nup Repeat Specificity. PLoS One. 2013 Dec 4;8(12):e80947. doi: 10.1371/journal.pone.0080947. PMID:24324649 doi:http://dx.doi.org/10.1371/journal.pone.0080947

1. ↑ Costa M, Ochem A, Staub A, Falaschi A. Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway. Nucleic Acids Res. 1999 Feb 1;27(3):817-21. PMID:9889278
2. ↑ Tourriere H, Gallouzi IE, Chebli K, Capony JP, Mouaikel J, van der Geer P, Tazi J. RasGAP-associated endoribonuclease G3Bp: selective RNA degradation and phosphorylation-dependent localization. Mol Cell Biol. 2001 Nov;21(22):7747-60. PMID:11604510 doi:10.1128/MCB.21.22.7747-7760.2001