4j3i

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4j3i| PDB=4j3i | SCENE= }}
 +
===X-ray crystal structure of bromodomain complex to 1.24 A resolution===
 +
{{ABSTRACT_PUBMED_24391744}}
-
The entry 4j3i is ON HOLD until Paper Publication
+
==Disease==
 +
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
-
Authors: Stein, A.J., White, A., Suto, R.K.
+
==Function==
 +
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
-
Description: X-ray crystal structure of bromodomain complex to 1.24 A resolution
+
==About this Structure==
 +
[[4j3i]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J3I OCA].
 +
 
 +
==Reference==
 +
<ref group="xtra">PMID:024391744</ref><references group="xtra"/><references/>
 +
[[Category: Stein, A J.]]
 +
[[Category: Suto, R K.]]
 +
[[Category: White, A.]]
 +
[[Category: Brd4]]
 +
[[Category: Bromodomain]]
 +
[[Category: Signaling protein-inhibitor complex]]

Revision as of 08:11, 15 January 2014

Template:STRUCTURE 4j3i

Contents

X-ray crystal structure of bromodomain complex to 1.24 A resolution

Template:ABSTRACT PUBMED 24391744

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

About this Structure

4j3i is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • McLure KG, Gesner EM, Tsujikawa L, Kharenko OA, Attwell S, Campeau E, Wasiak S, Stein A, White A, Fontano E, Suto RK, Wong NC, Wagner GS, Hansen HC, Young PR. RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist. PLoS One. 2013 Dec 31;8(12):e83190. doi: 10.1371/journal.pone.0083190. PMID:24391744 doi:http://dx.doi.org/10.1371/journal.pone.0083190
  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4j3i"
Personal tools