4jr0

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'''Unreleased structure'''
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{{STRUCTURE_4jr0| PDB=4jr0 | SCENE= }}
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===Human procaspase-3 bound to Ac-DEVD-CMK===
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The entry 4jr0 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
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Authors: Thomsen, N.D., Wells, J.A.
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==About this Structure==
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[[4jr0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JR0 OCA].
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Description:
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Caspase-3]]
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[[Category: Homo sapiens]]
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[[Category: Thomsen, N D.]]
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[[Category: Wells, J A.]]
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[[Category: Activity based probe]]
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[[Category: Apoptosis]]
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[[Category: Caspase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Irreversible inhibitor]]
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[[Category: Proenzyme]]
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[[Category: Protease]]
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[[Category: Protein-peptide complex]]

Revision as of 07:56, 8 May 2013

Template:STRUCTURE 4jr0

Contents

Human procaspase-3 bound to Ac-DEVD-CMK

Function

[CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.[1] [2]

About this Structure

4jr0 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, et al.. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature. 1995 Jul 6;376(6535):37-43. PMID:7596430 doi:http://dx.doi.org/10.1038/376037a0
  2. ↑ Cabrera JR, Bouzas-Rodriguez J, Tauszig-Delamasure S, Mehlen P. RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons. J Biol Chem. 2011 Apr 22;286(16):14628-38. doi: 10.1074/jbc.M110.195461. Epub, 2011 Feb 28. PMID:21357690 doi:10.1074/jbc.M110.195461

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