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4jup

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4jup| PDB=4jup | SCENE= }}
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===Dimeric structure of CARMA1 CARD===
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{{ABSTRACT_PUBMED_24224005}}
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The entry 4jup is ON HOLD
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==Disease==
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[[http://www.uniprot.org/uniprot/CAR11_HUMAN CAR11_HUMAN]] Persistent polyclonal B-cell lymphocytosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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Authors: Park, H.H.
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==Function==
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[[http://www.uniprot.org/uniprot/CAR11_HUMAN CAR11_HUMAN]] Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
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Description: Dimeric structure of CARMA1 CARD
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==About this Structure==
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[[4jup]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JUP OCA].
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==Reference==
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<ref group="xtra">PMID:024224005</ref><references group="xtra"/><references/>
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[[Category: Park, H H.]]
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[[Category: Protein binding]]
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[[Category: Protein interaction]]

Revision as of 11:03, 5 February 2014

Template:STRUCTURE 4jup

Contents

Dimeric structure of CARMA1 CARD

Template:ABSTRACT PUBMED 24224005

Disease

[CAR11_HUMAN] Persistent polyclonal B-cell lymphocytosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

[CAR11_HUMAN] Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.

About this Structure

4jup is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Jang TH, Park JH, Park HH. Novel disulfide bond-mediated dimerization of the CARD domain was revealed by the crystal structure of CARMA1 CARD. PLoS One. 2013 Nov 5;8(11):e79778. doi: 10.1371/journal.pone.0079778. eCollection, 2013. PMID:24224005 doi:http://dx.doi.org/10.1371/journal.pone.0079778

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