4k1c

From Proteopedia

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m (Protected "4k1c" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4k1c| PDB=4k1c | SCENE= }}
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===VCX1 Calcium/Proton Exchanger===
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The entry 4k1c is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/VCX1_YEAST VCX1_YEAST]] Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.<ref>PMID:8668190</ref> <ref>PMID:8628289</ref>
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Authors: Waight, A.B., Pedersen, B.P., Stroud, R.M., Center for Structures of Membrane Proteins (CSMP)
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==About this Structure==
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[[4k1c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1C OCA].
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Description: VCX1 Calcium/Proton Exchanger
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Saccharomyces cerevisiae s288c]]
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[[Category: CSMP, Center for Structures of Membrane Proteins.]]
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[[Category: Pedersen, B P.]]
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[[Category: Stroud, R M.]]
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[[Category: Waight, A B.]]
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[[Category: Calcium transport]]
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[[Category: Center for structures of membrane protein]]
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[[Category: Csmp]]
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[[Category: Membrane protein cax ncx nckx]]
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[[Category: Membrane protein-metal transport complex]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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[[Category: Transport protein]]
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[[Category: Vacuole]]

Revision as of 07:57, 8 May 2013

Template:STRUCTURE 4k1c

Contents

VCX1 Calcium/Proton Exchanger

Function

[VCX1_YEAST] Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.[1] [2]

About this Structure

4k1c is a 2 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

Reference

  1. ↑ Pozos TC, Sekler I, Cyert MS. The product of HUM1, a novel yeast gene, is required for vacuolar Ca2+/H+ exchange and is related to mammalian Na+/Ca2+ exchangers. Mol Cell Biol. 1996 Jul;16(7):3730-41. PMID:8668190
  2. ↑ Cunningham KW, Fink GR. Calcineurin inhibits VCX1-dependent H+/Ca2+ exchange and induces Ca2+ ATPases in Saccharomyces cerevisiae. Mol Cell Biol. 1996 May;16(5):2226-37. PMID:8628289

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