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4k1o

From Proteopedia

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m (Protected "4k1o" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4k1o| PDB=4k1o | SCENE= }}
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===Crystal structure of the alphaN-catenin actin-binding domain===
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{{ABSTRACT_PUBMED_23589308}}
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The entry 4k1o is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/CTNA2_MOUSE CTNA2_MOUSE]] May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.<ref>PMID:12089526</ref> <ref>PMID:12123610</ref> <ref>PMID:15034585</ref>
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Authors: Ishiyama, N., Ikura, M.
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==About this Structure==
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[[4k1o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1O OCA].
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Description: Crystal structure of the alphaN-catenin actin-binding domain
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Mus musculus]]
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[[Category: Ikura, M.]]
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[[Category: Ishiyama, N.]]
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[[Category: Alpha-catenin]]
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[[Category: Cell adhesion]]
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[[Category: F-actin]]
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[[Category: Five-helix bundle]]

Revision as of 07:41, 2 May 2013

Template:STRUCTURE 4k1o

Contents

Crystal structure of the alphaN-catenin actin-binding domain

Template:ABSTRACT PUBMED 23589308

Function

[CTNA2_MOUSE] May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.[1] [2] [3]

About this Structure

4k1o is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  1. ↑ Park C, Falls W, Finger JH, Longo-Guess CM, Ackerman SL. Deletion in Catna2, encoding alpha N-catenin, causes cerebellar and hippocampal lamination defects and impaired startle modulation. Nat Genet. 2002 Jul;31(3):279-84. Epub 2002 Jun 24. PMID:12089526 doi:10.1038/ng908
  2. ↑ Togashi H, Abe K, Mizoguchi A, Takaoka K, Chisaka O, Takeichi M. Cadherin regulates dendritic spine morphogenesis. Neuron. 2002 Jul 3;35(1):77-89. PMID:12123610
  3. ↑ Abe K, Chisaka O, Van Roy F, Takeichi M. Stability of dendritic spines and synaptic contacts is controlled by alpha N-catenin. Nat Neurosci. 2004 Apr;7(4):357-63. Epub 2004 Mar 21. PMID:15034585 doi:10.1038/nn1212

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