4bhx

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Revision as of 20:31, 17 April 2013 (edit) OCA (Talk | contribs) (New page: {{STRUCTURE_4bhx| PDB=4bhx | SCENE= }} ===Crystal structure of the SCAN domain from human paternally expressed gene 3 protein=== ==Function== [[http://www.uniprot.org/uniprot/PEG3_HU...) ← Previous diff

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Revision as of 20:31, 17 April 2013

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Template:STRUCTURE 4bhx

Contents 1 Crystal structure of the SCAN domain from human paternally expressed gene 3 protein 2 Function 3 About this Structure 4 Reference

Crystal structure of the SCAN domain from human paternally expressed gene 3 protein

Function

[PEG3_HUMAN] Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells.^[1]

About this Structure

4bhx is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

1. ↑ Kohda T, Asai A, Kuroiwa Y, Kobayashi S, Aisaka K, Nagashima G, Yoshida MC, Kondo Y, Kagiyama N, Kirino T, Kaneko-Ishino T, Ishino F. Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. Genes Cells. 2001 Mar;6(3):237-47. PMID:11260267