2erk

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[[Image:2erk.jpg|left|200px]]<br /><applet load="2erk" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2erk.jpg|left|200px]]
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caption="2erk, resolution 2.4&Aring;" />
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'''PHOSPHORYLATED MAP KINASE ERK2'''<br />
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{{Structure
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|PDB= 2erk |SIZE=350|CAPTION= <scene name='initialview01'>2erk</scene>, resolution 2.4&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= ERK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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}}
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'''PHOSPHORYLATED MAP KINASE ERK2'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2ERK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERK OCA].
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2ERK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERK OCA].
==Reference==
==Reference==
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Activation mechanism of the MAP kinase ERK2 by dual phosphorylation., Canagarajah BJ, Khokhlatchev A, Cobb MH, Goldsmith EJ, Cell. 1997 Sep 5;90(5):859-69. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9298898 9298898]
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Activation mechanism of the MAP kinase ERK2 by dual phosphorylation., Canagarajah BJ, Khokhlatchev A, Cobb MH, Goldsmith EJ, Cell. 1997 Sep 5;90(5):859-69. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9298898 9298898]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: serine/threonine-protein kinase]]
[[Category: serine/threonine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:13:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:43:34 2008''

Revision as of 14:43, 20 March 2008


PDB ID 2erk

Drag the structure with the mouse to rotate
, resolution 2.4Å
Gene: ERK2 (Rattus norvegicus)
Coordinates: save as pdb, mmCIF, xml



PHOSPHORYLATED MAP KINASE ERK2


Overview

The structure of the active form of the MAP kinase ERK2 has been solved, phosphorylated on a threonine and a tyrosine residue within the phosphorylation lip. The lip is refolded, bringing the phosphothreonine and phosphotyrosine into alignment with surface arginine-rich binding sites. Conformational changes occur in the lip and neighboring structures, including the P+1 site, the MAP kinase insertion, the C-terminal extension, and helix C. Domain rotation and remodeling of the proline-directed P+1 specificity pocket account for the activation. The conformation of the P+1 pocket is similar to a second proline-directed kinase, CDK2-CyclinA, thus permitting the origin of this specificity to be defined. Conformational changes outside the lip provide loci at which the state of phosphorylation can be felt by other cellular components.

About this Structure

2ERK is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Activation mechanism of the MAP kinase ERK2 by dual phosphorylation., Canagarajah BJ, Khokhlatchev A, Cobb MH, Goldsmith EJ, Cell. 1997 Sep 5;90(5):859-69. PMID:9298898

Page seeded by OCA on Thu Mar 20 16:43:34 2008

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