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2es4

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[[Image:2es4.gif|left|200px]]<br /><applet load="2es4" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2es4.gif|left|200px]]
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caption="2es4, resolution 1.85&Aring;" />
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'''Crystal structure of the Burkholderia glumae lipase-specific foldase in complex with its cognate lipase'''<br />
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{{Structure
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|PDB= 2es4 |SIZE=350|CAPTION= <scene name='initialview01'>2es4</scene>, resolution 1.85&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=IOD:IODIDE ION'>IOD</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3]
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|GENE= lifO, lipB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=337 Burkholderia glumae])
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}}
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'''Crystal structure of the Burkholderia glumae lipase-specific foldase in complex with its cognate lipase'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2ES4 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Burkholderia_glumae Burkholderia glumae] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=IOD:'>IOD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ES4 OCA].
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2ES4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Burkholderia_glumae Burkholderia glumae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ES4 OCA].
==Reference==
==Reference==
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Structure of a membrane-based steric chaperone in complex with its lipase substrate., Pauwels K, Lustig A, Wyns L, Tommassen J, Savvides SN, Van Gelder P, Nat Struct Mol Biol. 2006 Apr;13(4):374-5. Epub 2006 Mar 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16518399 16518399]
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Structure of a membrane-based steric chaperone in complex with its lipase substrate., Pauwels K, Lustig A, Wyns L, Tommassen J, Savvides SN, Van Gelder P, Nat Struct Mol Biol. 2006 Apr;13(4):374-5. Epub 2006 Mar 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16518399 16518399]
[[Category: Burkholderia glumae]]
[[Category: Burkholderia glumae]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: triacylglycerol hydrolase]]
[[Category: triacylglycerol hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:14:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:43:51 2008''

Revision as of 14:43, 20 March 2008

Image:2es4.gif


PDB ID 2es4

Drag the structure with the mouse to rotate
, resolution 1.85Å
Ligands: and
Gene: lifO, lipB (Burkholderia glumae)
Activity: Triacylglycerol lipase, with EC number 3.1.1.3
Coordinates: save as pdb, mmCIF, xml



Crystal structure of the Burkholderia glumae lipase-specific foldase in complex with its cognate lipase


Overview

Secretion via the type II secretion pathway in Gram-negative bacteria often relies crucially on steric chaperones in the periplasm. Here, we report the crystal structure of the soluble form of a lipase-specific foldase (Lif) from Burkholderia glumae in complex with its cognate lipase. The structure reveals how Lif uses a novel alpha-helical scaffold to embrace lipase, thereby creating an unusually extensive folding platform.

About this Structure

2ES4 is a Protein complex structure of sequences from Burkholderia glumae. Full crystallographic information is available from OCA.

Reference

Structure of a membrane-based steric chaperone in complex with its lipase substrate., Pauwels K, Lustig A, Wyns L, Tommassen J, Savvides SN, Van Gelder P, Nat Struct Mol Biol. 2006 Apr;13(4):374-5. Epub 2006 Mar 5. PMID:16518399

Page seeded by OCA on Thu Mar 20 16:43:51 2008

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