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3mku

From Proteopedia

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{{STRUCTURE_3mku| PDB=3mku | SCENE= }}
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==Structure of a Cation-bound Multidrug and Toxin Compound Extrusion (MATE) transporter==
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===Structure of a Cation-bound Multidrug and Toxin Compound Extrusion (MATE) transporter===
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<StructureSection load='3mku' size='340' side='right' caption='[[3mku]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
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{{ABSTRACT_PUBMED_20861838}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3mku]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MKU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RB:RUBIDIUM+ION'>RB</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3mkt|3mkt]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NorM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=666 Vibrio cholerae])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mku RCSB], [http://www.ebi.ac.uk/pdbsum/3mku PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mk/3mku_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Transporter proteins from the MATE (multidrug and toxic compound extrusion) family are vital in metabolite transport in plants, directly affecting crop yields worldwide. MATE transporters also mediate multiple-drug resistance (MDR) in bacteria and mammals, modulating the efficacy of many pharmaceutical drugs used in the treatment of a variety of diseases. MATE transporters couple substrate transport to electrochemical gradients and are the only remaining class of MDR transporters whose structure has not been determined. Here we report the X-ray structure of the MATE transporter NorM from Vibrio cholerae determined to 3.65 A, revealing an outward-facing conformation with two portals open to the outer leaflet of the membrane and a unique topology of the predicted 12 transmembrane helices distinct from any other known MDR transporter. We also report a cation-binding site in close proximity to residues previously deemed critical for transport. This conformation probably represents a stage of the transport cycle with high affinity for monovalent cations and low affinity for substrates.
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==About this Structure==
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Structure of a cation-bound multidrug and toxic compound extrusion transporter.,He X, Szewczyk P, Karyakin A, Evin M, Hong WX, Zhang Q, Chang G Nature. 2010 Oct 21;467(7318):991-4. Epub 2010 Sep 22. PMID:20861838<ref>PMID:20861838</ref>
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[[3mku]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MKU OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:020861838</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Vibrio cholerae]]
[[Category: Vibrio cholerae]]
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[[Category: Chang, G.]]
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[[Category: Chang, G]]
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[[Category: Evin, M.]]
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[[Category: Evin, M]]
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[[Category: He, X.]]
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[[Category: He, X]]
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[[Category: Hong, W X.]]
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[[Category: Hong, W X]]
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[[Category: Karyakin, A.]]
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[[Category: Karyakin, A]]
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[[Category: Szewczyk, P.]]
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[[Category: Szewczyk, P]]
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[[Category: Zhang, Q.]]
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[[Category: Zhang, Q]]
[[Category: Cation-bound]]
[[Category: Cation-bound]]
[[Category: Mate]]
[[Category: Mate]]
[[Category: Multidrug transporter]]
[[Category: Multidrug transporter]]
[[Category: Transport protein]]
[[Category: Transport protein]]

Revision as of 17:42, 18 December 2014

Structure of a Cation-bound Multidrug and Toxin Compound Extrusion (MATE) transporter

3mku, resolution 4.20Å

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