3ml4

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Template:STRUCTURE 3ml4

Contents

Crystal structure of a complex between Dok7 PH-PTB and the MuSK juxtamembrane region

Template:ABSTRACT PUBMED 20603078

Function

[DOK7_MOUSE] Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.[1] [2]

About this Structure

3ml4 is a 8 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Bergamin E, Hallock PT, Burden SJ, Hubbard SR. The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization. Mol Cell. 2010 Jul 9;39(1):100-9. PMID:20603078 doi:10.1016/j.molcel.2010.06.007
  1. ↑ Okada K, Inoue A, Okada M, Murata Y, Kakuta S, Jigami T, Kubo S, Shiraishi H, Eguchi K, Motomura M, Akiyama T, Iwakura Y, Higuchi O, Yamanashi Y. The muscle protein Dok-7 is essential for neuromuscular synaptogenesis. Science. 2006 Jun 23;312(5781):1802-5. PMID:16794080 doi:312/5781/1802
  2. ↑ Bergamin E, Hallock PT, Burden SJ, Hubbard SR. The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization. Mol Cell. 2010 Jul 9;39(1):100-9. PMID:20603078 doi:10.1016/j.molcel.2010.06.007

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OCA

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