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4k69

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4k69| PDB=4k69 | SCENE= }}
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===Crystal Structure of Human Chymase in Complex with Fragment Linked Benzimidazolone Inhibitor: (3S)-3-{3-[(6-bromo-2-oxo-2,3-dihydro-1H-indol-4-yl)methyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}hexanoic acid===
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{{ABSTRACT_PUBMED_23659209}}
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The entry 4k69 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/CMA1_HUMAN CMA1_HUMAN]] Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
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Authors: Collins, B.K., Padyana, A.K.
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==About this Structure==
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[[4k69]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K69 OCA].
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Description: Crystal Structure of Human Chymase complexed with fragment linked benzimidazolone inhibitor 2-[3-(6-Bromo-2-oxo-2,3-dihydro-1H-indol-4-ylmethyl)-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl]-hexanoic acid
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==Reference==
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<ref group="xtra">PMID:023659209</ref><references group="xtra"/><references/>
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[[Category: Chymase]]
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[[Category: Homo sapiens]]
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[[Category: Collins, B K.]]
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[[Category: Padyana, A K.]]
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[[Category: Glycosylated]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Mast cell]]
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[[Category: Secreted]]
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[[Category: Serine protease]]

Revision as of 13:22, 19 June 2013

Template:STRUCTURE 4k69

Contents

Crystal Structure of Human Chymase in Complex with Fragment Linked Benzimidazolone Inhibitor: (3S)-3-{3-[(6-bromo-2-oxo-2,3-dihydro-1H-indol-4-yl)methyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}hexanoic acid

Template:ABSTRACT PUBMED 23659209

Function

[CMA1_HUMAN] Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.

About this Structure

4k69 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Taylor SJ, Padyana AK, Abeywardane A, Liang S, Hao MH, De Lombaert S, Proudfoot JR, Farmer BS, Li X, Collins B, Albaugh DR, Martin L, Hill-Drzewi M, Pullen SS, Takahashi H. Discovery of Potent, Selective Chymase Inhibitors via Fragment Linking Strategies. J Med Chem. 2013 May 9. PMID:23659209 doi:10.1021/jm400138z

Proteopedia Page Contributors and Editors (what is this?)

OCA

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