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2f40
From Proteopedia
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| - | [[Image:2f40.gif|left|200px]] | + | [[Image:2f40.gif|left|200px]] |
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| - | '''Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction''' | + | {{Structure |
| + | |PDB= 2f40 |SIZE=350|CAPTION= <scene name='initialview01'>2f40</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2F40 is a [ | + | 2F40 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F40 OCA]. |
==Reference== | ==Reference== | ||
| - | Structure determination of a new protein from backbone-centered NMR data and NMR-assisted structure prediction., Mayer KL, Qu Y, Bansal S, LeBlond PD, Jenney FE Jr, Brereton PS, Adams MW, Xu Y, Prestegard JH, Proteins. 2006 Nov 1;65(2):480-9. PMID:[http:// | + | Structure determination of a new protein from backbone-centered NMR data and NMR-assisted structure prediction., Mayer KL, Qu Y, Bansal S, LeBlond PD, Jenney FE Jr, Brereton PS, Adams MW, Xu Y, Prestegard JH, Proteins. 2006 Nov 1;65(2):480-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16927360 16927360] |
[[Category: Pyrococcus furiosus]] | [[Category: Pyrococcus furiosus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: psi]] | [[Category: psi]] | ||
[[Category: pyrococcus furious]] | [[Category: pyrococcus furious]] | ||
| - | [[Category: residual dipolar | + | [[Category: residual dipolar coupling]] |
[[Category: secsg]] | [[Category: secsg]] | ||
[[Category: simulated annealing]] | [[Category: simulated annealing]] | ||
| - | [[Category: southeast collaboratory for structural | + | [[Category: southeast collaboratory for structural genomic]] |
| - | [[Category: structural | + | [[Category: structural genomic]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:47:49 2008'' |
Revision as of 14:47, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction
Overview
Targeting of proteins for structure determination in structural genomic programs often includes the use of threading and fold recognition methods to exclude proteins belonging to well-populated fold families, but such methods can still fail to recognize preexisting folds. The authors illustrate here a method in which limited amounts of structural data are used to improve an initial homology search and the data are subsequently used to produce a structure by data-constrained refinement of an identified structural template. The data used are primarily NMR-based residual dipolar couplings, but they also include additional chemical shift and backbone-nuclear Overhauser effect data. Using this methodology, a backbone structure was efficiently produced for a 10 kDa protein (PF1455) from Pyrococcus furiosus. Its relationship to existing structures and its probable function are discussed.
About this Structure
2F40 is a Single protein structure of sequence from Pyrococcus furiosus. Full crystallographic information is available from OCA.
Reference
Structure determination of a new protein from backbone-centered NMR data and NMR-assisted structure prediction., Mayer KL, Qu Y, Bansal S, LeBlond PD, Jenney FE Jr, Brereton PS, Adams MW, Xu Y, Prestegard JH, Proteins. 2006 Nov 1;65(2):480-9. PMID:16927360
Page seeded by OCA on Thu Mar 20 16:47:49 2008
Categories: Pyrococcus furiosus | Single protein | Bansal, S. | Prestegard, J H. | SECSG, Southeast Collaboratory for Structural Genomics. | Protein structure initiative | Protein structure prediction | Psi | Pyrococcus furious | Residual dipolar coupling | Secsg | Simulated annealing | Southeast collaboratory for structural genomic | Structural genomic
