4ezs
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of the substrate binding domain of E.coli DnaK in complex with metchnikowin (residues 20 to 26)== | |
| - | + | <StructureSection load='4ezs' size='340' side='right' caption='[[4ezs]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[4ezs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EZS FirstGlance]. <br> |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dkx|1dkx]], [[1dky|1dky]], [[1dkz|1dkz]], [[3dpo|3dpo]], [[3dpp|3dpp]], [[3dpq|3dpq]], [[3qnj|3qnj]], [[4e81|4e81]], [[4ezn|4ezn]], [[4ezo|4ezo]], [[4ezp|4ezp]], [[4ezq|4ezq]], [[4ezr|4ezr]], [[4ezt|4ezt]], [[4ezu|4ezu]], [[4ezv|4ezv]], [[4ezw|4ezw]], [[4ezx|4ezx]], [[4ezy|4ezy]], [[4ezz|4ezz]], [[4f00|4f00]], [[4f01|4f01]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b0014, dnaK, groP, grpF, JW0013, seg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K-12])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ezs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ezs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ezs RCSB], [http://www.ebi.ac.uk/pdbsum/4ezs PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI]] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332] [[http://www.uniprot.org/uniprot/MTK_DROME MTK_DROME]] Potent antifungal and antibacterial activity against Gram-positive bacteria. | [[http://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI]] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332] [[http://www.uniprot.org/uniprot/MTK_DROME MTK_DROME]] Potent antifungal and antibacterial activity against Gram-positive bacteria. | ||
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
[[Category: Escherichia coli k-12]] | [[Category: Escherichia coli k-12]] | ||
| - | [[Category: Straeter, N | + | [[Category: Straeter, N]] |
| - | [[Category: Zahn, M | + | [[Category: Zahn, M]] |
[[Category: Chaperone]] | [[Category: Chaperone]] | ||
[[Category: Chaperone-peptide binding protein complex]] | [[Category: Chaperone-peptide binding protein complex]] | ||
[[Category: Peptide binding]] | [[Category: Peptide binding]] | ||
Revision as of 07:58, 25 December 2014
Crystal structure of the substrate binding domain of E.coli DnaK in complex with metchnikowin (residues 20 to 26)
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