2f66
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2f66.gif|left|200px]] | + | [[Image:2f66.gif|left|200px]] |
| - | + | ||
| - | '''Structure of the ESCRT-I endosomal trafficking complex''' | + | {{Structure |
| + | |PDB= 2f66 |SIZE=350|CAPTION= <scene name='initialview01'>2f66</scene>, resolution 2.80Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= STP22, VPS23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), VPS28, VPT28 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), SRN2, VPS37 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | ||
| + | }} | ||
| + | |||
| + | '''Structure of the ESCRT-I endosomal trafficking complex''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2F66 is a [ | + | 2F66 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F66 OCA]. |
==Reference== | ==Reference== | ||
| - | Structural and functional organization of the ESCRT-I trafficking complex., Kostelansky MS, Sun J, Lee S, Kim J, Ghirlando R, Hierro A, Emr SD, Hurley JH, Cell. 2006 Apr 7;125(1):113-26. PMID:[http:// | + | Structural and functional organization of the ESCRT-I trafficking complex., Kostelansky MS, Sun J, Lee S, Kim J, Ghirlando R, Hierro A, Emr SD, Hurley JH, Cell. 2006 Apr 7;125(1):113-26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16615894 16615894] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| Line 20: | Line 29: | ||
[[Category: endosomal sorting complex required for transport]] | [[Category: endosomal sorting complex required for transport]] | ||
[[Category: endosome]] | [[Category: endosome]] | ||
| - | [[Category: escrt protein | + | [[Category: escrt protein complex]] |
[[Category: escrt-i]] | [[Category: escrt-i]] | ||
[[Category: trafficking complex]] | [[Category: trafficking complex]] | ||
| Line 30: | Line 39: | ||
[[Category: vps37]] | [[Category: vps37]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:48:34 2008'' |
Revision as of 14:48, 20 March 2008
| |||||||
| , resolution 2.80Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | STP22, VPS23 (Saccharomyces cerevisiae), VPS28, VPT28 (Saccharomyces cerevisiae), SRN2, VPS37 (Saccharomyces cerevisiae) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of the ESCRT-I endosomal trafficking complex
Overview
The endosomal sorting complex required for transport (ESCRT) complexes are central to receptor downregulation, lysosome biogenesis, and budding of HIV. The yeast ESCRT-I complex contains the Vps23, Vps28, and Vps37 proteins, and its assembly is directed by the C-terminal steadiness box of Vps23, the N-terminal half of Vps28, and the C-terminal half of Vps37. The crystal structures of a Vps23:Vps28 core subcomplex and the Vps23:Vps28:Vps37 core were solved at 2.1 and 2.8 A resolution. Each subunit contains a structurally similar pair of helices that form the core. The N-terminal domain of Vps28 has a hydrophobic binding site on its surface that is conformationally dynamic. The C-terminal domain of Vps28 binds the ESCRT-II complex. The structure shows how ESCRT-I is assembled by a compact core from which the Vps23 UEV domain, the Vps28 C domain, and other domains project to bind their partners.
About this Structure
2F66 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Structural and functional organization of the ESCRT-I trafficking complex., Kostelansky MS, Sun J, Lee S, Kim J, Ghirlando R, Hierro A, Emr SD, Hurley JH, Cell. 2006 Apr 7;125(1):113-26. PMID:16615894
Page seeded by OCA on Thu Mar 20 16:48:34 2008
Categories: Protein complex | Saccharomyces cerevisiae | Hurley, J H. | Kim, J. | Kostelansky, M S. | Lee, S. | SO4 | Endosomal sorting complex required for transport | Endosome | Escrt protein complex | Escrt-i | Trafficking complex | Tsg101 | Ubiquitin | Vacuolar protein sorting | Vps23 | Vps28 | Vps37
