2l9y
From Proteopedia
(Difference between revisions)
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| - | + | ==Solution structure of the MoCVNH-LysM module from the rice blast fungus Magnaporthe oryzae protein (MGG_03307)== | |
| - | + | <StructureSection load='2l9y' size='340' side='right' caption='[[2l9y]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[2l9y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Eukaryota Eukaryota]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L9Y FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MGG_03307 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2759 Eukaryota])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l9y RCSB], [http://www.ebi.ac.uk/pdbsum/2l9y PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The rice blast fungus Magnaporthe oryzae's genome encodes a hypothetical protein (MGG_03307) containing a type III CVNH lectin, in which a LysM domain is inserted between individual repeats of a single CVNH domain. At present, no structural or ligand binding data are available for any type III CVNH and functional studies in natural source organisms are scarce. Here, we report NMR solution structure and functional data on MGG_03307. The structure of the CVNH/LysM module revealed that intact and functionally competent CVNH and LysM domains are present. Using NMR titrations, carbohydrate specificities for both domains were determined, and it was found that each domain behaves as an isolated unit without any interdomain communication. Furthermore, live-cell imaging revealed a predominant localization of MGG_03307 within the appressorium, the specialized fungal cell for gaining entry into rice tissue. Our results suggest that MGG_03307 plays a role in the early stages of plant infection. | ||
| - | + | Structure-Function Analysis of a CVNH-LysM Lectin Expressed during Plant Infection by the Rice Blast Fungus Magnaporthe oryzae.,Koharudin LM, Viscomi AR, Montanini B, Kershaw MJ, Talbot NJ, Ottonello S, Gronenborn AM Structure. 2011 May 11;19(5):662-74. PMID:21565701<ref>PMID:21565701</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Eukaryota]] | [[Category: Eukaryota]] | ||
| - | [[Category: Gronenborn, A M | + | [[Category: Gronenborn, A M]] |
| - | [[Category: Kershaw, M J | + | [[Category: Kershaw, M J]] |
| - | [[Category: Koharudin, L M.I | + | [[Category: Koharudin, L M.I]] |
| - | [[Category: Montanini, B | + | [[Category: Montanini, B]] |
| - | [[Category: Ottonello, S | + | [[Category: Ottonello, S]] |
| - | [[Category: Talbot, N J | + | [[Category: Talbot, N J]] |
| - | [[Category: Viscomi, A R | + | [[Category: Viscomi, A R]] |
[[Category: Carbohydrate]] | [[Category: Carbohydrate]] | ||
[[Category: Cvnh]] | [[Category: Cvnh]] | ||
[[Category: Lectin]] | [[Category: Lectin]] | ||
[[Category: Sugar binding protein]] | [[Category: Sugar binding protein]] | ||
Revision as of 12:46, 18 December 2014
Solution structure of the MoCVNH-LysM module from the rice blast fungus Magnaporthe oryzae protein (MGG_03307)
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