2f8i

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[[Image:2f8i.gif|left|200px]]<br /><applet load="2f8i" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2f8i.gif|left|200px]]
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caption="2f8i, resolution 1.541&Aring;" />
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'''Human transthyretin (TTR) complexed with Benzoxazole'''<br />
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{{Structure
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|PDB= 2f8i |SIZE=350|CAPTION= <scene name='initialview01'>2f8i</scene>, resolution 1.541&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=205:2-(2,6-DICHLOROPHENYL)-1,3-BENZOXAZOLE-6-CARBOXYLIC ACID'>205</scene>
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|ACTIVITY=
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|GENE= TTR, PALB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Human transthyretin (TTR) complexed with Benzoxazole'''
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==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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2F8I is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=205:'>205</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8I OCA].
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2F8I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8I OCA].
==Reference==
==Reference==
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Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action., Razavi H, Palaninathan SK, Powers ET, Wiseman RL, Purkey HE, Mohamedmohaideen NN, Deechongkit S, Chiang KP, Dendle MT, Sacchettini JC, Kelly JW, Angew Chem Int Ed Engl. 2003 Jun 23;42(24):2758-61. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12820260 12820260]
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Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action., Razavi H, Palaninathan SK, Powers ET, Wiseman RL, Purkey HE, Mohamedmohaideen NN, Deechongkit S, Chiang KP, Dendle MT, Sacchettini JC, Kelly JW, Angew Chem Int Ed Engl. 2003 Jun 23;42(24):2758-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12820260 12820260]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: ttr; amyloid; transthyretin]]
[[Category: ttr; amyloid; transthyretin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:18:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:49:22 2008''

Revision as of 14:49, 20 March 2008

Image:2f8i.gif


PDB ID 2f8i

Drag the structure with the mouse to rotate
, resolution 1.541Å
Ligands:
Gene: TTR, PALB (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Human transthyretin (TTR) complexed with Benzoxazole


Disease

Known diseases associated with this structure: Amyloid neuropathy, familial, several allelic types OMIM:[176300], Amyloidosis, senile systemic OMIM:[176300], Carpal tunnel syndrome, familial OMIM:[176300], Dystransthyretinemic hyperthyroxinemia OMIM:[176300]

About this Structure

2F8I is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action., Razavi H, Palaninathan SK, Powers ET, Wiseman RL, Purkey HE, Mohamedmohaideen NN, Deechongkit S, Chiang KP, Dendle MT, Sacchettini JC, Kelly JW, Angew Chem Int Ed Engl. 2003 Jun 23;42(24):2758-61. PMID:12820260

Page seeded by OCA on Thu Mar 20 16:49:22 2008

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