3nk3

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{{STRUCTURE_3nk3| PDB=3nk3 | SCENE= }}
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==Crystal structure of full-length sperm receptor ZP3 at 2.6 A resolution==
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===Crystal structure of full-length sperm receptor ZP3 at 2.6 A resolution===
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<StructureSection load='3nk3' size='340' side='right' caption='[[3nk3]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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{{ABSTRACT_PUBMED_20970175}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3nk3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NK3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3d4c|3d4c]], [[3d4g|3d4g]], [[3ef7|3ef7]], [[3nk4|3nk4]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nk3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nk3 RCSB], [http://www.ebi.ac.uk/pdbsum/3nk3 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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ZP3, a major component of the zona pellucida (ZP) matrix coating mammalian eggs, is essential for fertilization by acting as sperm receptor. By retaining a propeptide that contains a polymerization-blocking external hydrophobic patch (EHP), we determined the crystal structure of an avian homolog of ZP3 at 2.0 A resolution. The structure unveils the fold of a complete ZP domain module in a homodimeric arrangement required for secretion and reveals how EHP prevents premature incorporation of ZP3 into the ZP. This suggests mechanisms underlying polymerization and how local structural differences, reflected by alternative disulfide patterns, control the specificity of ZP subunit interaction. Close relative positioning of a conserved O-glycan important for sperm binding and the hypervariable, positively selected C-terminal region of ZP3 suggests a concerted role in the regulation of species-restricted gamete recognition. Alternative conformations of the area around the O-glycan indicate how sperm binding could trigger downstream events via intramolecular signaling.
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==Function==
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Insights into egg coat assembly and egg-sperm interaction from the X-ray structure of full-length ZP3.,Han L, Monne M, Okumura H, Schwend T, Cherry AL, Flot D, Matsuda T, Jovine L Cell. 2010 Oct 29;143(3):404-15. Epub 2010 Oct 21. PMID:20970175<ref>PMID:20970175</ref>
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[[http://www.uniprot.org/uniprot/P79762_CHICK P79762_CHICK]] Component of the zona pellucida, which mediates species-specific sperm binding. Directly binds to sperm. Important for egg fertilization.<ref>PMID:15115720</ref> <ref>PMID:20970175</ref>
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[3nk3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NK3 OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020970175</ref><ref group="xtra">PMID:007418009</ref><ref group="xtra">PMID:012021773</ref><ref group="xtra">PMID:015079052</ref><ref group="xtra">PMID:015952882</ref><ref group="xtra">PMID:019052627</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Jovine, L.]]
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[[Category: Jovine, L]]
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[[Category: Monne , M.]]
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[[Category: Monne , M]]
[[Category: Biodiversity]]
[[Category: Biodiversity]]
[[Category: Cell adhesion]]
[[Category: Cell adhesion]]

Revision as of 15:05, 18 December 2014

Crystal structure of full-length sperm receptor ZP3 at 2.6 A resolution

3nk3, resolution 2.60Å

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