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3ny7

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{{STRUCTURE_3ny7| PDB=3ny7 | SCENE= }}
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==STAS domain of YchM bound to ACP==
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===STAS domain of YchM bound to ACP===
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<StructureSection load='3ny7' size='340' side='right' caption='[[3ny7]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
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{{ABSTRACT_PUBMED_21070944}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ny7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NY7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SXM:3-{[2-({N-[(2S)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]SULFANYL}-3-OXOPROPANOIC+ACID'>SXM</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ychM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ny7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ny7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ny7 RCSB], [http://www.ebi.ac.uk/pdbsum/3ny7 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Escherichia coli YchM is a member of the SLC26 (SulP) family of anion transporters with an N-terminal membrane domain and a C-terminal cytoplasmic STAS domain. Mutations in human members of the SLC26 family, including their STAS domain, are linked to a number of inherited diseases. Herein, we describe the high-resolution crystal structure of the STAS domain from E. coli YchM isolated in complex with acyl-carrier protein (ACP), an essential component of the fatty acid biosynthesis (FAB) pathway. A genome-wide genetic interaction screen showed that a ychM null mutation is synthetically lethal with mutant alleles of genes (fabBDHGAI) involved in FAB. Endogenous YchM also copurified with proteins involved in fatty acid metabolism. Furthermore, a deletion strain lacking ychM showed altered cellular bicarbonate incorporation in the presence of NaCl and impaired growth at alkaline pH. Thus, identification of the STAS-ACP complex suggests that YchM sequesters ACP to the bacterial membrane linking bicarbonate transport with fatty acid metabolism.
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==Function==
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Structure of a SLC26 anion transporter STAS domain in complex with acyl carrier protein: implications for E. coli YchM in fatty acid metabolism.,Babu M, Greenblatt JF, Emili A, Strynadka NC, Reithmeier RA, Moraes TF Structure. 2010 Nov 10;18(11):1450-62. PMID:21070944<ref>PMID:21070944</ref>
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[[http://www.uniprot.org/uniprot/C5W3Z7_ECOBB C5W3Z7_ECOBB]] Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity).[RuleBase:RU003545][HAMAP-Rule:MF_01217]
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[3ny7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY7 OCA].
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</div>
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==Reference==
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==See Also==
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<ref group="xtra">PMID:021070944</ref><references group="xtra"/><references/>
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*[[Acyl carrier protein|Acyl carrier protein]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Moraes, T F.]]
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[[Category: Moraes, T F]]
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[[Category: Reithmeier, R.]]
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[[Category: Reithmeier, R]]
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[[Category: Strynadka, N C.S.]]
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[[Category: Strynadka, N C.S]]
[[Category: 4'-phosphopantetheine]]
[[Category: 4'-phosphopantetheine]]
[[Category: Acyl carrier protein]]
[[Category: Acyl carrier protein]]

Revision as of 07:24, 19 December 2014

STAS domain of YchM bound to ACP

3ny7, resolution 1.92Å

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