2fa0
From Proteopedia
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| - | [[Image:2fa0.gif|left|200px]] | + | [[Image:2fa0.gif|left|200px]] |
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| - | '''HMG-CoA synthase from Brassica juncea in complex with HMG-CoA and covalently bound to HMG-CoA''' | + | {{Structure |
| + | |PDB= 2fa0 |SIZE=350|CAPTION= <scene name='initialview01'>2fa0</scene>, resolution 2.49Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=HMG:3-HYDROXY-3-METHYLGLUTARYL-COENZYME A'>HMG</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''HMG-CoA synthase from Brassica juncea in complex with HMG-CoA and covalently bound to HMG-CoA''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2FA0 is a [ | + | 2FA0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Brassica_juncea Brassica juncea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FA0 OCA]. |
==Reference== | ==Reference== | ||
| - | Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases., Pojer F, Ferrer JL, Richard SB, Nagegowda DA, Chye ML, Bach TJ, Noel JP, Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11491-6. Epub 2006 Jul 24. PMID:[http:// | + | Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases., Pojer F, Ferrer JL, Richard SB, Nagegowda DA, Chye ML, Bach TJ, Noel JP, Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11491-6. Epub 2006 Jul 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16864776 16864776] |
[[Category: Brassica juncea]] | [[Category: Brassica juncea]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: hmgs1]] | [[Category: hmgs1]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:49:54 2008'' |
Revision as of 14:49, 20 March 2008
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| , resolution 2.49Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
HMG-CoA synthase from Brassica juncea in complex with HMG-CoA and covalently bound to HMG-CoA
Overview
3-Hydroxy-3-methylglutaryl CoA synthase (HMGS) catalyzes the first committed step in the mevalonate metabolic pathway for isoprenoid biosynthesis and serves as an alternative target for cholesterol-lowering and antibiotic drugs. We have determined a previously undescribed crystal structure of a eukaryotic HMGS bound covalently to a potent and specific inhibitor F-244 [(E,E)-11-[3-(hydroxymethyl)-4-oxo-2-oxytanyl]-3,5,7-trimethyl-2,4-undecad ienenoic acid]. Given the accessibility of synthetic analogs of the F-244 natural product, this inhibited eukaryotic HMGS structure serves as a necessary starting point for structure-based methods that may improve the potency and species-specific selectivity of the next generation of F-244 analogs designed to target particular eukaryotic and prokaryotic HMGS.
About this Structure
2FA0 is a Single protein structure of sequence from Brassica juncea. Full crystallographic information is available from OCA.
Reference
Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases., Pojer F, Ferrer JL, Richard SB, Nagegowda DA, Chye ML, Bach TJ, Noel JP, Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11491-6. Epub 2006 Jul 24. PMID:16864776
Page seeded by OCA on Thu Mar 20 16:49:54 2008
Categories: Brassica juncea | Single protein | Ferrer, J L. | Noel, J P. | Pojer, F. | Richard, S B. | HMG | Hmg-coa | Hmgs1
