2fbe

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[[Image:2fbe.gif|left|200px]]<br /><applet load="2fbe" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2fbe.gif|left|200px]]
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caption="2fbe, resolution 2.52&Aring;" />
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'''Crystal Structure of the PRYSPRY-domain'''<br />
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{{Structure
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|PDB= 2fbe |SIZE=350|CAPTION= <scene name='initialview01'>2fbe</scene>, resolution 2.52&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= gene 19q13.4.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Crystal Structure of the PRYSPRY-domain'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2FBE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FBE OCA].
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2FBE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FBE OCA].
==Reference==
==Reference==
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Structure of the PRYSPRY-domain: implications for autoinflammatory diseases., Grutter C, Briand C, Capitani G, Mittl PR, Papin S, Tschopp J, Grutter MG, FEBS Lett. 2006 Jan 9;580(1):99-106. Epub 2005 Dec 9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16364311 16364311]
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Structure of the PRYSPRY-domain: implications for autoinflammatory diseases., Grutter C, Briand C, Capitani G, Mittl PR, Papin S, Tschopp J, Grutter MG, FEBS Lett. 2006 Jan 9;580(1):99-106. Epub 2005 Dec 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16364311 16364311]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: jellyroll beta-sandwich fold]]
[[Category: jellyroll beta-sandwich fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:19:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:50:20 2008''

Revision as of 14:50, 20 March 2008

Image:2fbe.gif


PDB ID 2fbe

Drag the structure with the mouse to rotate
, resolution 2.52Å
Gene: gene 19q13.4.1 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of the PRYSPRY-domain


Overview

We determined the first structure of PRYSPRY, a domain found in over 500 different proteins, involved in innate immune signaling, cytokine signaling suppression, development, cell growth and retroviral restriction. The fold encompasses a 7-stranded and a 6-stranded antiparallel beta-sheet, arranged in a beta-sandwich. In the crystal, PRYSPRY forms a dimer where the C-terminus of an acceptor molecule binds to the concave surface of a donor molecule, which represents a putative interaction site. Mutations in the PRYSPRY domains of Pyrin, which are responsible for familial Mediterranean fever, map on the putative PRYSPRY interaction site.

About this Structure

2FBE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the PRYSPRY-domain: implications for autoinflammatory diseases., Grutter C, Briand C, Capitani G, Mittl PR, Papin S, Tschopp J, Grutter MG, FEBS Lett. 2006 Jan 9;580(1):99-106. Epub 2005 Dec 9. PMID:16364311

Page seeded by OCA on Thu Mar 20 16:50:20 2008

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