Androgen receptor
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| - | '''Androgen receptor''' (AR) is a nuclear receptor which is activated by testosterone or 5-α-dihydrotestosterone (DHT). Upon binding the androgenic hormone it translocates to the nucleus where it acts as a DNA-binding transcription factor. The AR binds to a specific sequence of DNA called hormone response element. AR binds to other proteins in the nucleus causing up- or down gene regulation. AR exists in two isoforms. AR-B is full length 110 kDa and AR-A (87 kDa) lacks the N-terminal 187 amino acids. AR structure is composed of 5 domains - <br /> | + | '''Androgen receptor''' (AR) is a nuclear receptor which is activated by testosterone or 5-α-dihydrotestosterone (DHT) [[hormone]]. Upon binding the androgenic hormone it translocates to the nucleus where it acts as a DNA-binding transcription factor. The AR binds to a specific sequence of DNA called hormone response element. AR binds to other proteins in the nucleus causing up- or down gene regulation. AR exists in two isoforms. AR-B is full length 110 kDa and AR-A (87 kDa) lacks the N-terminal 187 amino acids. AR structure is composed of 5 domains - <br /> |
A/B: N-terminal contains the activation functions and dimerization surface<br /> | A/B: N-terminal contains the activation functions and dimerization surface<br /> | ||
C: DNA binding domain (DBD)<br /> | C: DNA binding domain (DBD)<br /> | ||
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[[2ao6]] – hAR + nuclear receptor coactivator 2 peptide<br /> | [[2ao6]] – hAR + nuclear receptor coactivator 2 peptide<br /> | ||
[[1xj7]] – hAR + DHT + RAC3 peptide<br /> | [[1xj7]] – hAR + DHT + RAC3 peptide<br /> | ||
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| + | ==See Also== | ||
| + | * [[Hormone]] | ||
Revision as of 23:15, 29 April 2013
Androgen receptor (AR) is a nuclear receptor which is activated by testosterone or 5-α-dihydrotestosterone (DHT) hormone. Upon binding the androgenic hormone it translocates to the nucleus where it acts as a DNA-binding transcription factor. The AR binds to a specific sequence of DNA called hormone response element. AR binds to other proteins in the nucleus causing up- or down gene regulation. AR exists in two isoforms. AR-B is full length 110 kDa and AR-A (87 kDa) lacks the N-terminal 187 amino acids. AR structure is composed of 5 domains -
A/B: N-terminal contains the activation functions and dimerization surface
C: DNA binding domain (DBD)
D: Hinge region between DBD and LBD
E: Ligand binding domain (LBD) which binds the N-terminal FXXFL motif
F: C-terminal domain
Contents |
3D Structures of androgen receptor
Updated on 29-April-2013
AR DBD domain
1r4i – rAR (mutant) + DNA – rat
AR LBD domain
AR LBD domain complex with testosterone or DHT
1i37 – rAR + DHT
1i38 – rAR (mutant) + DHT
2ama – hAR + DHT - human
1t7t – cAR + DHT - chimpanzee
2ylo, 2ylp, 2ylq, 3zqt, 4hlw – hAR + testosterone + benzoate derivative
2pio, 2pip, 2piq, 2pir, 2pit, 2piu, 2piv, 2piw, 2pix, 2pkl, 2qpy – hAR + DHT + small molecule
2yhd – hAR + testosterone + small molecule
2am9 – rAR + testosterone
Other AR LBD domain complexes
1e3g, 1xq3 – hAR + androgen
1gs4 – hAR (mutant) + corticosteroid
1z95, 3rlj – hAR + anti-androgen
2oz7, 3rll – hAR (mutant) + anti-androgen
2ax6, 2ax7, 2ax8 – hAR (mutant) + nonsteroidal ligand
2ax9, 2axa – hAR + nonsteroidal ligand
2amb, 2pnu – hAR + steroid
1xnn – rAR (mutant) + nonsteroidal ligand
2ihq, 2nw4, 3g0w – rAR + modulator
2hvc, 3b5r, 3b65, 3b66, 3b67, 3b68 – hAR + modulator
AR LBD domain complex with peptide
1t73, 1t74, 1t76, 1t79, 1t7f, 1t7m, 1t7r – cAR + FXXFF-type peptide
1xow – hAR + androgen + FXXFF-type peptide
2q7i – hAR + testosterone + FXXFF-type peptide
3v49, 3v4a – hAR + modulator + FXXFF-type peptide
1t5z – hAR + DHT + nuclear receptor coactivator 1 peptide
1t63, 1t65 – hAR + DHT + nuclear receptor coactivator 2 peptide
3l3x, 3l3z – hAR + DHT + nuclear receptor coactivator 3 peptide
2z4j – hAR + DHT + nuclear receptor 0B2 peptide
2q7j – hAR + testosterone + nuclear receptor coactivator 2 peptide
2q7k, 2q7l – hAR (mutant) + testosterone + nuclear receptor coactivator 2 peptide
2ao6 – hAR + nuclear receptor coactivator 2 peptide
1xj7 – hAR + DHT + RAC3 peptide
See Also
Proteopedia Page Contributors and Editors (what is this?)
Cristina Benito, Michal Harel, Cristina Murga, Marta Roldan Lazaro, Alexander Berchansky, Joel L. Sussman, Wayne Decatur, David Sánchez Fernández
