2fcw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2fcw.gif|left|200px]]<br /><applet load="2fcw" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:2fcw.gif|left|200px]]
-
caption="2fcw, resolution 1.26&Aring;" />
+
 
-
'''Structure of a Complex Between the Pair of the LDL Receptor Ligand-Binding Modules 3-4 and the Receptor Associated Protein (RAP).'''<br />
+
{{Structure
 +
|PDB= 2fcw |SIZE=350|CAPTION= <scene name='initialview01'>2fcw</scene>, resolution 1.26&Aring;
 +
|SITE=
 +
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> and <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
 +
|ACTIVITY=
 +
|GENE= LDLR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
 +
}}
 +
 
 +
'''Structure of a Complex Between the Pair of the LDL Receptor Ligand-Binding Modules 3-4 and the Receptor Associated Protein (RAP).'''
 +
 
==Overview==
==Overview==
Line 10: Line 19:
==About this Structure==
==About this Structure==
-
2FCW is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=NA:'>NA</scene> and <scene name='pdbligand=MPD:'>MPD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCW OCA].
+
2FCW is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCW OCA].
==Reference==
==Reference==
-
Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors., Fisher C, Beglova N, Blacklow SC, Mol Cell. 2006 Apr 21;22(2):277-83. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16630895 16630895]
+
Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors., Fisher C, Beglova N, Blacklow SC, Mol Cell. 2006 Apr 21;22(2):277-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16630895 16630895]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
Line 28: Line 37:
[[Category: rap]]
[[Category: rap]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:20:07 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:50:52 2008''

Revision as of 14:50, 20 March 2008

Image:2fcw.gif


PDB ID 2fcw

Drag the structure with the mouse to rotate
, resolution 1.26Å
Ligands: , and
Gene: LDLR (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Structure of a Complex Between the Pair of the LDL Receptor Ligand-Binding Modules 3-4 and the Receptor Associated Protein (RAP).


Contents

Overview

Proteins of the low-density lipoprotein receptor (LDLR) family are remarkable in their ability to bind an extremely diverse range of protein and lipoprotein ligands, yet the basis for ligand recognition is poorly understood. Here, we report the 1.26 A X-ray structure of a complex between a two-module region of the ligand binding domain of the LDLR and the third domain of RAP, an escort protein for LDLR family members. The RAP domain forms a three-helix bundle with two docking sites, one for each LDLR module. The mode of recognition at each site is virtually identical: three conserved, calcium-coordinating acidic residues from each LDLR module encircle a lysine side chain protruding from the second helix of RAP. This metal-dependent mode of electrostatic recognition, together with avidity effects resulting from the use of multiple sites, represents a general binding strategy likely to apply in the binding of other basic ligands to LDLR family proteins.

Disease

Known disease associated with this structure: Hypercholesterolemia, familial OMIM:[606945]

About this Structure

2FCW is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors., Fisher C, Beglova N, Blacklow SC, Mol Cell. 2006 Apr 21;22(2):277-83. PMID:16630895

Page seeded by OCA on Thu Mar 20 16:50:52 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2fcw"
Personal tools