User:Fadel A. Samatey/FlhBc I
From Proteopedia
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(→Molecular Tour: FlhBc Structures) |
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===Flexibility of N-Terminus=== | ===Flexibility of N-Terminus=== | ||
| - | Molecular dynamics simulations suggested that the mutations in 281-285 reduced flexibility of the N-terminal alpha helix, and hence that such flexibility may be important for function. Indeed, 226-267 (the N-terminal helix) is predicted to be intrinsically disordered<ref><img src='Image:3b0z-FlhB-Foldindex.png'</ref>. The formation of a helix seems likely to be the result of stabilization by crystal contacts mentioned above. | + | Molecular dynamics simulations suggested that the mutations in 281-285 reduced flexibility of the N-terminal alpha helix, and hence that such flexibility may be important for function. Indeed, 226-267 (the N-terminal helix) is predicted to be intrinsically disordered<ref><img src='Image:3b0z-FlhB-Foldindex.png'></ref>. The formation of a helix seems likely to be the result of stabilization by crystal contacts mentioned above. |
</StructureSection> | </StructureSection> | ||
===References and Notes=== | ===References and Notes=== | ||
Revision as of 09:44, 30 April 2013
Interactive 3D Complement in Proteopedia
Inhibition of a type III secretion system by the deletion of a short loop in one of its membrane proteins.
Vladimir A. Meshcheryakov, Akio Kitao, Hideyuki Matsunami and Fadel A. Samatey (サマテ). Acta Cryst. D69: 812-820 (2013). doi:10.1107/S0907444913002102
Brief Introduction
FlhB is a membrane protein that is part of the flagellum-specific secretion apparatus. It is required for secretion of flagellar proteins, and for bacterial motility. FlhB is paralogous to a protein in the virulence type III secretion system. FlhB has a hydrophobic integral membrane domain, predicted to have four transmembrane helices, a flexible linker that is highly conserved and essential for function, and a cytoplasmic domain. The present study reports the structures of the cytoplasmic domains of two bacterial taxa. (Please see the publication for a more detailed introduction.)
Molecular Tour: FlhBc Structures
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References and Notes
- ↑ Optimum growth ~90o C.
- ↑ <img src='Image:3b0z-FlhB-Foldindex.png'>
