Retinoid X receptor
From Proteopedia
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| - | <StructureSection load='1g5y' size=' | + | <StructureSection load='1g5y' size='350' side='right' caption='Structure of human retinoid X receptor ligand-binding domain tetramer complex with retinoid (PDB entry [[1g5y]])' scene=''> |
'''Retinoid X receptor''' (RXR) is a nuclear receptor activated by 9-cis retinoic acid. RXR makes a heterodimer with subfamily 1 nuclear receptors including retinoic acid receptor (RAR). In the absence of ligand, the RAR/RXR complex binds the hormone response elements complexed with corepressor protein. Upon binding of the ligand, the corepressor disassociates from the receptor and associates with the coactivator leading to transcription activation. RAR contains a DNA-binding domain (DBD) and ligand-binding domain (LBD). There are 3 classes of RXR: α, β and γ. For additional details on RXR-α see [[RA Mediated T-reg Differentiation]]. | '''Retinoid X receptor''' (RXR) is a nuclear receptor activated by 9-cis retinoic acid. RXR makes a heterodimer with subfamily 1 nuclear receptors including retinoic acid receptor (RAR). In the absence of ligand, the RAR/RXR complex binds the hormone response elements complexed with corepressor protein. Upon binding of the ligand, the corepressor disassociates from the receptor and associates with the coactivator leading to transcription activation. RAR contains a DNA-binding domain (DBD) and ligand-binding domain (LBD). There are 3 classes of RXR: α, β and γ. For additional details on RXR-α see [[RA Mediated T-reg Differentiation]]. | ||
Revision as of 07:39, 1 May 2013
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