4k39

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'''Unreleased structure'''
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{{STRUCTURE_4k39| PDB=4k39 | SCENE= }}
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===Native anSMEcpe with bound AdoMet and Cp18Cys peptide===
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The entry 4k39 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/ANSME_CLOP1 ANSME_CLOP1]] Involved in 'Cys-type' sulfatase maturation under anaerobic conditions. Catalyzes the post-translational modification of cysteine ('Cys-51' in the arylsulfatase CPF_0221) into 3-oxoalanine (also known as C(alpha)-formylglycine (FGly)), by a free radical chemical mechanism initiated via the reductive cleavage of S-adenosyl-L-methionine (SAM). Is also able to oxidize a serine residue in a synthetic substrate to FGly in vitro, and in a serine variant of a Cys-type sulfatase in vivo, but this activity is not physiological.<ref>PMID:16766528</ref> <ref>PMID:17335281</ref> <ref>PMID:18408004</ref>
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Authors: Goldman, P.J., Drennan, C.L.
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==About this Structure==
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[[4k39]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens_atcc_13124 Clostridium perfringens atcc 13124]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K39 OCA].
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Description: Native anSMEcpe with bound AdoMet and Cp18Cys peptide
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Clostridium perfringens atcc 13124]]
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[[Category: Drennan, C L.]]
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[[Category: Goldman, P J.]]
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[[Category: Adomet radical fold]]
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[[Category: Oxidoreductase]]

Revision as of 07:58, 8 May 2013

Template:STRUCTURE 4k39

Contents

Native anSMEcpe with bound AdoMet and Cp18Cys peptide

Function

[ANSME_CLOP1] Involved in 'Cys-type' sulfatase maturation under anaerobic conditions. Catalyzes the post-translational modification of cysteine ('Cys-51' in the arylsulfatase CPF_0221) into 3-oxoalanine (also known as C(alpha)-formylglycine (FGly)), by a free radical chemical mechanism initiated via the reductive cleavage of S-adenosyl-L-methionine (SAM). Is also able to oxidize a serine residue in a synthetic substrate to FGly in vitro, and in a serine variant of a Cys-type sulfatase in vivo, but this activity is not physiological.[1] [2] [3]

About this Structure

4k39 is a 4 chain structure with sequence from Clostridium perfringens atcc 13124. Full crystallographic information is available from OCA.

Reference

  1. ↑ Berteau O, Guillot A, Benjdia A, Rabot S. A new type of bacterial sulfatase reveals a novel maturation pathway in prokaryotes. J Biol Chem. 2006 Aug 11;281(32):22464-70. Epub 2006 Jun 9. PMID:16766528 doi:M602504200
  2. ↑ Benjdia A, Leprince J, Guillot A, Vaudry H, Rabot S, Berteau O. Anaerobic sulfatase-maturating enzymes: radical SAM enzymes able to catalyze in vitro sulfatase post-translational modification. J Am Chem Soc. 2007 Mar 28;129(12):3462-3. Epub 2007 Mar 3. PMID:17335281 doi:10.1021/ja067175e
  3. ↑ Benjdia A, Subramanian S, Leprince J, Vaudry H, Johnson MK, Berteau O. Anaerobic sulfatase-maturating enzymes, first dual substrate radical S-adenosylmethionine enzymes. J Biol Chem. 2008 Jun 27;283(26):17815-26. doi: 10.1074/jbc.M710074200. Epub 2008, Apr 11. PMID:18408004 doi:10.1074/jbc.M710074200

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