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4ka4

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4ka4| PDB=4ka4 | SCENE= }}
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===Crystal structure of a proteolytically defined Zbeta domain of human DAI (ZBP1, DLM-1)===
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The entry 4ka4 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN]] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).
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Authors: Athanasiadis, A., de Rosa, M., De Sanctis, D.
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==About this Structure==
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[[4ka4]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KA4 OCA].
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Description: Crystal structure of a proteolytically defined Zbeta domain of human DAI (ZBP1, DLM-1)
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[[Category: Homo sapiens]]
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[[Category: Athanasiadis, A.]]
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[[Category: Rosa, M de.]]
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[[Category: Sanctis, D De.]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Dna sensor]]
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[[Category: Whth]]
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[[Category: Z-dna binding]]

Revision as of 07:34, 16 May 2013

Template:STRUCTURE 4ka4

Crystal structure of a proteolytically defined Zbeta domain of human DAI (ZBP1, DLM-1)

Function

[ZBP1_HUMAN] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).

About this Structure

4ka4 is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

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OCA

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