2fic
From Proteopedia
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| - | [[Image:2fic.gif|left|200px]] | + | [[Image:2fic.gif|left|200px]] |
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| - | '''The crystal structure of the BAR domain from human Bin1/Amphiphysin II and its implications for molecular recognition''' | + | {{Structure |
| + | |PDB= 2fic |SIZE=350|CAPTION= <scene name='initialview01'>2fic</scene>, resolution 1.99Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=XE:XENON'>XE</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''The crystal structure of the BAR domain from human Bin1/Amphiphysin II and its implications for molecular recognition''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2FIC is a [ | + | 2FIC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FIC OCA]. |
==Reference== | ==Reference== | ||
| - | The crystal structure of the BAR domain from human Bin1/amphiphysin II and its implications for molecular recognition., Casal E, Federici L, Zhang W, Fernandez-Recio J, Priego EM, Miguel RN, DuHadaway JB, Prendergast GC, Luisi BF, Laue ED, Biochemistry. 2006 Oct 31;45(43):12917-28. PMID:[http:// | + | The crystal structure of the BAR domain from human Bin1/amphiphysin II and its implications for molecular recognition., Casal E, Federici L, Zhang W, Fernandez-Recio J, Priego EM, Miguel RN, DuHadaway JB, Prendergast GC, Luisi BF, Laue ED, Biochemistry. 2006 Oct 31;45(43):12917-28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17059209 17059209] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: XE]] | [[Category: XE]] | ||
[[Category: bar domain]] | [[Category: bar domain]] | ||
| - | [[Category: coiled- | + | [[Category: coiled-coil]] |
[[Category: homodimer]] | [[Category: homodimer]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:52:44 2008'' |
Revision as of 14:52, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
The crystal structure of the BAR domain from human Bin1/Amphiphysin II and its implications for molecular recognition
Contents |
Overview
BAR domains are found in proteins that bind and remodel membranes and participate in cytoskeletal and nuclear processes. Here, we report the crystal structure of the BAR domain from the human Bin1 protein at 2.0 A resolution. Both the quaternary and tertiary architectures of the homodimeric Bin1BAR domain are built upon "knobs-into-holes" packing of side chains, like those found in conventional left-handed coiled-coils, and this packing governs the curvature of a putative membrane-engaging concave face. Our calculations indicate that the Bin1BAR domain contains two potential sites for protein-protein interactions on the convex face of the dimer. Comparative analysis of structural features reveals that at least three architectural subtypes of the BAR domain are encoded in the human genome, represented by the Arfaptin, Bin1/Amphiphysin, and IRSp53 BAR domains. We discuss how these principal groups may differ in their potential to form regulatory heterotypic interactions.
Disease
Known diseases associated with this structure: Myopathy, centronuclear, autosomal recessive OMIM:[601248]
About this Structure
2FIC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The crystal structure of the BAR domain from human Bin1/amphiphysin II and its implications for molecular recognition., Casal E, Federici L, Zhang W, Fernandez-Recio J, Priego EM, Miguel RN, DuHadaway JB, Prendergast GC, Luisi BF, Laue ED, Biochemistry. 2006 Oct 31;45(43):12917-28. PMID:17059209
Page seeded by OCA on Thu Mar 20 16:52:44 2008
