2f83
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2f83.gif|left|200px]] | + | [[Image:2f83.gif|left|200px]] |
| - | + | ||
| - | '''Crystal structure of a human coagulation factor''' | + | {{Structure |
| + | |PDB= 2f83 |SIZE=350|CAPTION= <scene name='initialview01'>2f83</scene>, resolution 2.87Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=PT:PLATINUM (II) ION'>PT</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of a human coagulation factor''' | ||
| + | |||
| + | |||
| + | ==Overview== | ||
| + | Factor XI (FXI), a coagulation protein essential to normal hemostasis, circulates as a disulfide-linked dimer. Here we report the full-length FXI zymogen crystal structure, revealing that the protease and four apple domains assemble into a unique 'cup and saucer' architecture. The structure shows that the thrombin and platelet glycoprotein Ib binding sites are remote within the monomer but lie in close proximity across the dimer, suggesting a transactivation mechanism. | ||
==Disease== | ==Disease== | ||
| Line 7: | Line 19: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2F83 is a [ | + | 2F83 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F83 OCA]. |
| + | |||
| + | ==Reference== | ||
| + | Crystal structure of the factor XI zymogen reveals a pathway for transactivation., Papagrigoriou E, McEwan PA, Walsh PN, Emsley J, Nat Struct Mol Biol. 2006 Jun;13(6):557-8. Epub 2006 May 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16699514 16699514] | ||
[[Category: Coagulation factor XIa]] | [[Category: Coagulation factor XIa]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| Line 20: | Line 35: | ||
[[Category: protease]] | [[Category: protease]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:49:11 2008'' |
Revision as of 14:49, 20 March 2008
| |||||||
| , resolution 2.87Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | and | ||||||
| Activity: | Coagulation factor XIa, with EC number 3.4.21.27 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of a human coagulation factor
Contents |
Overview
Factor XI (FXI), a coagulation protein essential to normal hemostasis, circulates as a disulfide-linked dimer. Here we report the full-length FXI zymogen crystal structure, revealing that the protease and four apple domains assemble into a unique 'cup and saucer' architecture. The structure shows that the thrombin and platelet glycoprotein Ib binding sites are remote within the monomer but lie in close proximity across the dimer, suggesting a transactivation mechanism.
Disease
Known diseases associated with this structure: Factor XI deficiency, autosomal dominant OMIM:[264900], Factor XI deficiency, autosomal recessive OMIM:[264900]
About this Structure
2F83 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the factor XI zymogen reveals a pathway for transactivation., Papagrigoriou E, McEwan PA, Walsh PN, Emsley J, Nat Struct Mol Biol. 2006 Jun;13(6):557-8. Epub 2006 May 14. PMID:16699514
Page seeded by OCA on Thu Mar 20 16:49:11 2008
