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4f3c
From Proteopedia
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{{STRUCTURE_4f3c| PDB=4f3c | SCENE= }} | {{STRUCTURE_4f3c| PDB=4f3c | SCENE= }} | ||
===Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with butyl-thio-DADMe-Immucillin-A=== | ===Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with butyl-thio-DADMe-Immucillin-A=== | ||
| + | {{ABSTRACT_PUBMED_23685211}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4f3c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_choleraesuis_str._scsa50 Salmonella enterica subsp. enterica serovar choleraesuis str. scsa50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F3C OCA]. | [[4f3c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_choleraesuis_str._scsa50 Salmonella enterica subsp. enterica serovar choleraesuis str. scsa50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F3C OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023685211</ref><references group="xtra"/><references/> | ||
[[Category: Adenosylhomocysteine nucleosidase]] | [[Category: Adenosylhomocysteine nucleosidase]] | ||
[[Category: Salmonella enterica subsp. enterica serovar choleraesuis str. scsa50]] | [[Category: Salmonella enterica subsp. enterica serovar choleraesuis str. scsa50]] | ||
Revision as of 08:18, 19 June 2013
Contents |
Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with butyl-thio-DADMe-Immucillin-A
Template:ABSTRACT PUBMED 23685211
Function
[E8NLP5_SALET] Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity).[HAMAP-Rule:MF_01684]
About this Structure
4f3c is a 2 chain structure with sequence from Salmonella enterica subsp. enterica serovar choleraesuis str. scsa50. Full crystallographic information is available from OCA.
Reference
- Haapalainen AM, Thomas K, Tyler PC, Evans GB, Almo SC, Schramm VL. Salmonella enterica MTAN at 1.36 A Resolution: A Structure-Based Design of Tailored Transition State Analogs. Structure. 2013 May 14. pii: S0969-2126(13)00121-4. doi:, 10.1016/j.str.2013.04.009. PMID:23685211 doi:10.1016/j.str.2013.04.009
Categories: Adenosylhomocysteine nucleosidase | Salmonella enterica subsp. enterica serovar choleraesuis str. scsa50 | Almo, S C. | Bonanno, J B. | Haapalainen, A M. | Schramm, V L. | Thomas, K. | 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase | Acting on glycosyl bond | Adenosylhomocysteine nucleosidase activity | Hydrolase-hydrolase inhibitor complex | L-methionine biosynthetic process from s-adenosylmethionine | L-methionine salvage from methylthioadenosine | Methylthioadenosine nucleosidase activity
