2l7x
From Proteopedia
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| - | + | ==Crimean Congo Hemorrhagic Fever Gn zinc finger== | |
| - | ===Crimean Congo | + | <StructureSection load='2l7x' size='340' side='right' caption='[[2l7x]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[2l7x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Crimean-congo_hemorrhagic_fever_virus Crimean-congo hemorrhagic fever virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L7X FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GPC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11593 Crimean-Congo hemorrhagic fever virus])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l7x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l7x RCSB], [http://www.ebi.ac.uk/pdbsum/2l7x PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The RNA virus that causes the Crimean Congo Hemorrhagic Fever (CCHF) is a tick-borne pathogen of the Nairovirus genus, family Bunyaviridae. Unlike many zoonotic viruses that are only passed between animals and humans, the CCHF virus can also be transmitted from human to human with an overall mortality rate approaching 30%. Currently, there are no atomic structures for any CCHF virus proteins or for any Nairovirus proteins. A critical component of the virus is the envelope Gn glycoprotein, which contains a C-terminal cytoplasmic tail. In other Bunyaviridae viruses, the Gn tail has been implicated in host-pathogen interaction and viral assembly. Here we report the NMR structure of the CCHF virus Gn cytoplasmic tail, residues 729-805. The structure contains a pair of tightly arranged dual betabetaalpha zinc fingers similar to those found in the Hantavirus genus, with which it shares about 12% sequence identity. Unlike Hantavirus zinc fingers, however, the CCHF virus zinc fingers bind viral RNA and contain contiguous clusters of conserved surface electrostatics. Our results provide insight into a likely role of the CCHF virus Gn zinc fingers in Nairovirus assembly. | ||
| - | + | Structural characterization of the crimean-congo hemorrhagic Fever virus gn tail provides insight into virus assembly.,Estrada DF, De Guzman RN J Biol Chem. 2011 Jun 17;286(24):21678-86. Epub 2011 Apr 20. PMID:21507948<ref>PMID:21507948</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Crimean-congo hemorrhagic fever virus]] | [[Category: Crimean-congo hemorrhagic fever virus]] | ||
| - | [[Category: Estrada, D F | + | [[Category: Estrada, D F]] |
| - | [[Category: Guzman, R N.De | + | [[Category: Guzman, R N.De]] |
[[Category: Cytoplasmic tail]] | [[Category: Cytoplasmic tail]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
Revision as of 11:23, 18 December 2014
Crimean Congo Hemorrhagic Fever Gn zinc finger
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