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3ou5

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Template:STRUCTURE 3ou5

Contents

HUMAN MITOCHONDRIAL SERINE HYDROXYMETHYLTRANSFERASe 2

Function

[GLYM_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA.[1]

About this Structure

3ou5 is a 1 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2a7v. Full crystallographic information is available from OCA.

Reference

  1. ↑ Anderson DD, Quintero CM, Stover PJ. Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15163-8. doi:, 10.1073/pnas.1103623108. Epub 2011 Aug 26. PMID:21876188 doi:10.1073/pnas.1103623108

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OCA

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