2fp7
From Proteopedia
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| - | [[Image:2fp7.gif|left|200px]] | + | [[Image:2fp7.gif|left|200px]] |
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| - | '''West Nile Virus NS2B/NS3protease in complex with Bz-Nle-Lys-Arg-Arg-H''' | + | {{Structure |
| + | |PDB= 2fp7 |SIZE=350|CAPTION= <scene name='initialview01'>2fp7</scene>, resolution 1.68Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NDL:N-BENZOYL-L-NORLEUCYL-L-LYSYL-L-ARGINYL-L-ARGININE'>NDL</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Flavivirin Flavivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.91 3.4.21.91] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''West Nile Virus NS2B/NS3protease in complex with Bz-Nle-Lys-Arg-Arg-H''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2FP7 is a [ | + | 2FP7 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/West_nile_virus West nile virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FP7 OCA]. |
==Reference== | ==Reference== | ||
| - | Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus., Erbel P, Schiering N, D'Arcy A, Renatus M, Kroemer M, Lim SP, Yin Z, Keller TH, Vasudevan SG, Hommel U, Nat Struct Mol Biol. 2006 Apr;13(4):372-3. Epub 2006 Mar 12. PMID:[http:// | + | Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus., Erbel P, Schiering N, D'Arcy A, Renatus M, Kroemer M, Lim SP, Yin Z, Keller TH, Vasudevan SG, Hommel U, Nat Struct Mol Biol. 2006 Apr;13(4):372-3. Epub 2006 Mar 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16532006 16532006] |
[[Category: Flavivirin]] | [[Category: Flavivirin]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: substrate-based inhibitor]] | [[Category: substrate-based inhibitor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:55:08 2008'' |
Revision as of 14:55, 20 March 2008
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| , resolution 1.68Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Activity: | Flavivirin, with EC number 3.4.21.91 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
West Nile Virus NS2B/NS3protease in complex with Bz-Nle-Lys-Arg-Arg-H
Overview
The replication of flaviviruses requires the correct processing of their polyprotein by the viral NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of NS2B. Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. These structures identify key residues for NS3pro substrate recognition and clarify the mechanism of NS3pro activation.
About this Structure
2FP7 is a Protein complex structure of sequences from West nile virus. Full crystallographic information is available from OCA.
Reference
Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus., Erbel P, Schiering N, D'Arcy A, Renatus M, Kroemer M, Lim SP, Yin Z, Keller TH, Vasudevan SG, Hommel U, Nat Struct Mol Biol. 2006 Apr;13(4):372-3. Epub 2006 Mar 12. PMID:16532006
Page seeded by OCA on Thu Mar 20 16:55:08 2008
