3b0f

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{{STRUCTURE_3b0f| PDB=3b0f | SCENE= }}
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==Crystal structure of the UBA domain of p62 and its interaction with ubiquitin==
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===Crystal structure of the UBA domain of p62 and its interaction with ubiquitin===
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<StructureSection load='3b0f' size='340' side='right' caption='[[3b0f]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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{{ABSTRACT_PUBMED_021715324}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3b0f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B0F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2rru|2rru]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Sqstm1, A170, STAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b0f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b0f RCSB], [http://www.ebi.ac.uk/pdbsum/3b0f PDBsum]</span></td></tr>
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</table>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/SQSTM_MOUSE SQSTM_MOUSE]] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.<ref>PMID:14960283</ref> <ref>PMID:18382763</ref>
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*[[Sequestosome|Sequestosome]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3b0f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0F OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Arita, K.]]
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[[Category: Arita, K]]
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[[Category: Hasegawa, J.]]
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[[Category: Hasegawa, J]]
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[[Category: Isogai, S.]]
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[[Category: Isogai, S]]
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[[Category: Komatsu, M.]]
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[[Category: Komatsu, M]]
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[[Category: Morimoto, D.]]
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[[Category: Morimoto, D]]
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[[Category: Shirakawa, M.]]
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[[Category: Shirakawa, M]]
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[[Category: Sou, Y.]]
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[[Category: Sou, Y]]
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[[Category: Tanaka, K.]]
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[[Category: Tanaka, K]]
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[[Category: Tenno, T.]]
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[[Category: Tenno, T]]
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[[Category: Tochio, H.]]
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[[Category: Tochio, H]]
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[[Category: Unzai, S.]]
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[[Category: Unzai, S]]
[[Category: Autophagy]]
[[Category: Autophagy]]
[[Category: Protein binding]]
[[Category: Protein binding]]
[[Category: Ubiquitin]]
[[Category: Ubiquitin]]

Revision as of 14:24, 18 December 2014

Crystal structure of the UBA domain of p62 and its interaction with ubiquitin

3b0f, resolution 1.40Å

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