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STILL MAKING FINAL ADDITIONS
STILL MAKING FINAL ADDITIONS
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Under normal circumstances, the voltage gated sodium channel, or (VGSC), serve to propagate the action potential down the axon, responding to elevated intracellular potential by opening the channel, allowing the rapid influx of sodium ions, which elevates the potential further, propagating the action potential. In a seizure, the synchronized activity of action potentials leads to very high frequency action potentials, leading to muscular convulsions and other symptoms <ref>McCormick DA, Contreras D. On the cellular and network bases of epileptic seizures. Annu Rev Physiol. 2001;63:815-46.</ref>(McCormick et. al, 2001). However, anticonvulsant drugs suppress seizures by limiting the high frequency firing of action potentials. These drugs do not interfere heavily with normal neurological activity, because they have little effect in neurons with normal resting potentials (Rogawski and Löscher, 2004).
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Under normal circumstances, the voltage gated sodium channel, or (VGSC), serve to propagate the action potential down the axon, responding to elevated intracellular potential by opening the channel, allowing the rapid influx of sodium ions, which elevates the potential further, propagating the action potential. In a seizure, the synchronized activity of action potentials leads to very high frequency action potentials, leading to muscular convulsions and other symptoms <ref>McCormick DA, Contreras D. On the cellular and network bases of epileptic seizures. Annu Rev Physiol. 2001;63:815-46.</ref>. However, anticonvulsant drugs suppress seizures by limiting the high frequency firing of action potentials. These drugs do not interfere heavily with normal neurological activity, because they have little effect in neurons with normal resting potentials <ref>Rogawski, M., & Löscher, W. (2004). The neurobiology of antiepileptic drugs. Nature Reviews. Neuroscience, 5(7), 553-564.</ref>
Structural determination of the <scene name='Sandbox_Reserved_695/Vgsc_original/1'>VGSC</scene> has revealed it to be composed of four homologous domains, each of which has six transmembrane regions, while the pore is composed of the S5 and S6 segments (Sato et al., 2001). For a better illustration of the structure, see [http://genomebiology.com/content/figures/gb-2003-4-3-207-1.jpg Schematic of Transmembrane regions of VGSC] (REF).
Structural determination of the <scene name='Sandbox_Reserved_695/Vgsc_original/1'>VGSC</scene> has revealed it to be composed of four homologous domains, each of which has six transmembrane regions, while the pore is composed of the S5 and S6 segments (Sato et al., 2001). For a better illustration of the structure, see [http://genomebiology.com/content/figures/gb-2003-4-3-207-1.jpg Schematic of Transmembrane regions of VGSC] (REF).

Revision as of 13:05, 4 May 2013

This Sandbox is Reserved from 30/01/2013, through 30/12/2013 for use in the course "Biochemistry II" taught by Hannah Tims at the Messiah College. This reservation includes Sandbox Reserved 686 through Sandbox Reserved 700.
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Contents

Epileptic drugs at Voltage-Gated Sodium Ion Channel

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Introduction

STILL MAKING FINAL ADDITIONS

Under normal circumstances, the voltage gated sodium channel, or (VGSC), serve to propagate the action potential down the axon, responding to elevated intracellular potential by opening the channel, allowing the rapid influx of sodium ions, which elevates the potential further, propagating the action potential. In a seizure, the synchronized activity of action potentials leads to very high frequency action potentials, leading to muscular convulsions and other symptoms [1]. However, anticonvulsant drugs suppress seizures by limiting the high frequency firing of action potentials. These drugs do not interfere heavily with normal neurological activity, because they have little effect in neurons with normal resting potentials [2] Structural determination of the has revealed it to be composed of four homologous domains, each of which has six transmembrane regions, while the pore is composed of the S5 and S6 segments (Sato et al., 2001). For a better illustration of the structure, see Schematic of Transmembrane regions of VGSC (REF).

Structure

Interactions

Active Site

Mechanism

Inhibitors

Interactions/effectors

Other Stuff??

References

  1. ↑ McCormick DA, Contreras D. On the cellular and network bases of epileptic seizures. Annu Rev Physiol. 2001;63:815-46.
  2. ↑ Rogawski, M., & Löscher, W. (2004). The neurobiology of antiepileptic drugs. Nature Reviews. Neuroscience, 5(7), 553-564.

Original=



____/5 Background info ____/5 Structural elements ____Structure ____Description ____/5 Interactions ____Structure ____Description ____/5 Active site ____Structure ____Description ____/5 Mechanism ____Structure ____Description ____/5 Inhibitors ____Structure ____Description ____/5 Interactions/ effectors ___Structure ____Description ____ additional cool stuff. ____Structure ____Description

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