User:Samuel Carlson/Sandbox 1
From Proteopedia
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=Bromodomain adjacent to zinc finger domain protein 2A (BAZ2a)= | =Bromodomain adjacent to zinc finger domain protein 2A (BAZ2a)= | ||
| - | <StructureSection load='3g0l' size='350' side='right' caption='Structure of BAZ2b bromodomain (PDB entry [[3g0l]]), BAZ2a similar' scene=''> | ||
| - | Anything in this section will appear adjacent to the 3D structure and will be scrollable. | ||
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| - | </StructureSection> | ||
{{STRUCTURE_3g0l| PDB=3g0l | SCENE= }} | {{STRUCTURE_3g0l| PDB=3g0l | SCENE= }} | ||
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==Role in the Nucleolar Remodeling Complex (NoRC)== | ==Role in the Nucleolar Remodeling Complex (NoRC)== | ||
| + | [[Image:Example.jpg]] | ||
BAZ2A interacts with sucrose-nonfermenting protein 2 homolog (SNF2H) to form the NoRC, which recruits histone methyltransferases, histone deacetylases, and DNA methyltransferases. The NoRC silences transcription by modifying DNA compaction, as well as by interfering with ribosomal RNA (rRNA) transcription. (CITE) BAZ2a is thought to direct transcriptional repression by binding to histones labeled with posttranslational modifications (PTMs) such as acetylation on lysine residues. | BAZ2A interacts with sucrose-nonfermenting protein 2 homolog (SNF2H) to form the NoRC, which recruits histone methyltransferases, histone deacetylases, and DNA methyltransferases. The NoRC silences transcription by modifying DNA compaction, as well as by interfering with ribosomal RNA (rRNA) transcription. (CITE) BAZ2a is thought to direct transcriptional repression by binding to histones labeled with posttranslational modifications (PTMs) such as acetylation on lysine residues. | ||
==Evolution and related structures== | ==Evolution and related structures== | ||
| - | The bromodomain | + | The bromodomain is a highly conserved structure within BAZ2a. It can be found in many large proteins associated with helicase activity, chromatin remodeling, methyl- or acetyltransferase activity, or transcriptional control. <ref>PMID:22464331</ref> |
=BAZ2a Function= | =BAZ2a Function= | ||
Revision as of 05:01, 7 May 2013
Contents |
Bromodomain adjacent to zinc finger domain protein 2A (BAZ2a)
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| 3g0l, resolution 2.03Å () | |||||||||
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| Ligands: | |||||||||
| Gene: | BAZ2B (Homo sapiens) | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Role in the Nucleolar Remodeling Complex (NoRC)
BAZ2A interacts with sucrose-nonfermenting protein 2 homolog (SNF2H) to form the NoRC, which recruits histone methyltransferases, histone deacetylases, and DNA methyltransferases. The NoRC silences transcription by modifying DNA compaction, as well as by interfering with ribosomal RNA (rRNA) transcription. (CITE) BAZ2a is thought to direct transcriptional repression by binding to histones labeled with posttranslational modifications (PTMs) such as acetylation on lysine residues.
Evolution and related structures
The bromodomain is a highly conserved structure within BAZ2a. It can be found in many large proteins associated with helicase activity, chromatin remodeling, methyl- or acetyltransferase activity, or transcriptional control. [1]
BAZ2a Function
Role in Chromatin Remodeling
As a critical member of the NoRC, BAZ2a in conjunction with SNF2H is responsible for modifying the compaction of chromatin, through The NoRC is also responsible for ribosomal DNA (rDNA) transcription silencing, by recruiting histone deacetylase (HDAC) and DNA methyltransferase (DNMT) to the rDNA promoter, effectively creating a region with the characteristics of heterochromatin and silencing rDNA transcription. [2]
Medical Implications
References
- ↑ Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Muller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S. Histone recognition and large-scale structural analysis of the human bromodomain family. Cell. 2012 Mar 30;149(1):214-31. PMID:22464331 doi:10.1016/j.cell.2012.02.013
- ↑ Santoro R, Li J, Grummt I. The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. Nat Genet. 2002 Nov;32(3):393-6. Epub 2002 Oct 7. PMID:12368916 doi:10.1038/ng1010
