2lu3
From Proteopedia
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| - | + | {{STRUCTURE_2lu3| PDB=2lu3 | SCENE= }} | |
| + | ===Solution NMR structure of the apo-form of the beta2 carbohydrate module of AMP-activated protein kinase=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/AAKB2_RAT AAKB2_RAT]] Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity). | ||
| - | + | ==About this Structure== | |
| - | + | [[2lu3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU3 OCA]. | |
| - | + | [[Category: Rattus norvegicus]] | |
| + | [[Category: Gooley, P.]] | ||
| + | [[Category: Koay, A.]] | ||
| + | [[Category: Stapleton, D.]] | ||
| + | [[Category: Carbohydrate binding module]] | ||
| + | [[Category: Glycogen binding]] | ||
| + | [[Category: Sugar binding protein]] | ||
Revision as of 21:00, 19 June 2013
Solution NMR structure of the apo-form of the beta2 carbohydrate module of AMP-activated protein kinase
Function
[AAKB2_RAT] Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity).
About this Structure
2lu3 is a 1 chain structure with sequence from Rattus norvegicus. Full experimental information is available from OCA.
