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4bkx

From Proteopedia

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m (Protected "4bkx" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4bkx| PDB=4bkx | SCENE= }}
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===The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex===
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{{ABSTRACT_PUBMED_23791785}}
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The entry 4bkx is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/MTA1_HUMAN MTA1_HUMAN]] May be involved in the regulation of gene expression by covalent modification of histone proteins. Isoform Long is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER.
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Authors: Millard, C.J., Watson, P.J., Celardo, I., Gordiyenko, Y., Cowley, S.M., Robinson, C.V., Fairall, L., Schwabe, J.W.R.
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==About this Structure==
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[[4bkx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKX OCA].
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Description: The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex
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==Reference==
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<ref group="xtra">PMID:023791785</ref><references group="xtra"/><references/>
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[[Category: Histone deacetylase]]
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[[Category: Homo sapiens]]
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[[Category: Celardo, I.]]
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[[Category: Cowley, S M.]]
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[[Category: Fairall, L.]]
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[[Category: Gordiyenko, Y.]]
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[[Category: Millard, C J.]]
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[[Category: Robinson, C V.]]
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[[Category: Schwabe, J W.R.]]
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[[Category: Watson, P J.]]
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[[Category: Elm2-sant domain]]
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[[Category: Hdac]]
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[[Category: Hdac1]]
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[[Category: Histone deacetylase]]
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[[Category: Inositol phosphate signalling]]
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[[Category: Mta1]]
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[[Category: Transcription]]

Revision as of 13:58, 3 July 2013

Template:STRUCTURE 4bkx

Contents

The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex

Template:ABSTRACT PUBMED 23791785

Function

[MTA1_HUMAN] May be involved in the regulation of gene expression by covalent modification of histone proteins. Isoform Long is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER.

About this Structure

4bkx is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Millard CJ, Watson PJ, Celardo I, Gordiyenko Y, Cowley SM, Robinson CV, Fairall L, Schwabe JW. Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates. Mol Cell. 2013 Jun 19. pii: S1097-2765(13)00407-3. doi:, 10.1016/j.molcel.2013.05.020. PMID:23791785 doi:10.1016/j.molcel.2013.05.020

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OCA

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