4k8v
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | {{STRUCTURE_4k8v| PDB=4k8v | SCENE= }} | |
| + | ===Structure of cyclic GMP-AMP Synthase (cGAS)=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. | ||
| - | + | ==About this Structure== | |
| - | + | [[4k8v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K8V OCA]. | |
| - | + | [[Category: Mus musculus]] | |
| + | [[Category: Gao, P.]] | ||
| + | [[Category: Patel, D J.]] | ||
| + | [[Category: Wu, Y.]] | ||
| + | [[Category: Dna]] | ||
| + | [[Category: Nucleotidyltransferase]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 07:33, 16 May 2013
Structure of cyclic GMP-AMP Synthase (cGAS)
Function
[CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
About this Structure
4k8v is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
