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4k97

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4k97| PDB=4k97 | SCENE= }}
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===Structure of Ternary Complex of cGAS with dsDNA and Bound ATP===
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The entry 4k97 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
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Authors: Gao, P., Wu, Y., Patel, D.J.
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==About this Structure==
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[[4k97]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K97 OCA].
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Description: Structure of Ternary Complex of cGAS with dsDNA and Bound ATP
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[[Category: Mus musculus]]
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[[Category: Gao, P.]]
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[[Category: Patel, D J.]]
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[[Category: Wu, Y.]]
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[[Category: Nucleotidyltransferase fold]]
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[[Category: Transferase-dna complex]]

Revision as of 07:33, 16 May 2013

Template:STRUCTURE 4k97

Structure of Ternary Complex of cGAS with dsDNA and Bound ATP

Function

[CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.

About this Structure

4k97 is a 3 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

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OCA

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