4kcc

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'''Unreleased structure'''
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{{STRUCTURE_4kcc| PDB=4kcc | SCENE= }}
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===Crystal Structure of the NMDA Receptor GluN1 Ligand Binding Domain Apo State===
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The entry 4kcc is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref>
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Authors: Berger, A.J., Lau, A.Y., Mayer, M.L.
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==About this Structure==
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[[4kcc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KCC OCA].
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Description: Crystal Structure of the NMDA Receptor GluN1 Ligand Binding Domain Apo State
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Rattus norvegicus]]
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[[Category: Berger, A J.]]
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[[Category: Lau, A Y.]]
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[[Category: Mayer, M L.]]
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[[Category: Membrane protein]]

Revision as of 05:22, 1 August 2013

Template:STRUCTURE 4kcc

Contents

Crystal Structure of the NMDA Receptor GluN1 Ligand Binding Domain Apo State

Function

[NMDZ1_RAT] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.[1]

About this Structure

4kcc is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  1. ↑ Inanobe A, Furukawa H, Gouaux E. Mechanism of partial agonist action at the NR1 subunit of NMDA receptors. Neuron. 2005 Jul 7;47(1):71-84. PMID:15996549 doi:10.1016/j.neuron.2005.05.022

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OCA

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