4kgg

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m (Protected "4kgg" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4kgg| PDB=4kgg | SCENE= }}
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===Crystal structure of light mutant2 and dcr3 complex===
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The entry 4kgg is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/TNF6B_HUMAN TNF6B_HUMAN]] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.<ref>PMID:21300286</ref> [[http://www.uniprot.org/uniprot/TNF14_HUMAN TNF14_HUMAN]] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
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Authors: Liu, W., Bonanno, J.B., Zhan, C., Prakash, R., Toro, R., Nathenson, S.G., Almo, S.C., Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC)
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==About this Structure==
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[[4kgg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_acetobutylicum Clostridium acetobutylicum] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGG OCA].
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Description: Crystal structure of light mutant2 and dcr3 complex
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Clostridium acetobutylicum]]
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[[Category: Homo sapiens]]
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[[Category: Almo, S C.]]
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[[Category: Bonanno, J B.]]
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[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]]
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[[Category: Liu, W.]]
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[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]
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[[Category: Nathenson, S G.]]
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[[Category: Prakash, R.]]
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[[Category: Toro, R.]]
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[[Category: Zhan, C.]]
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[[Category: Atoms-to-animals: the immune function network]]
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[[Category: Bind tnf receptor hvem and ltbr]]
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[[Category: Cytokine]]
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[[Category: Cytokine-signaling protein complex]]
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[[Category: Dcr3]]
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[[Category: Ifn]]
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[[Category: Immune system]]
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[[Category: Jelly-roll fold]]
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[[Category: Light]]
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[[Category: Ltbr]]
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[[Category: Membrane]]
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[[Category: N-glycosylation]]
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[[Category: New hvem]]
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[[Category: New york structural genomics research consortium]]
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[[Category: Nysgrc]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Secreted protein]]
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[[Category: Structural genomic]]
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[[Category: Tnf]]
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[[Category: Tnf14]]
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[[Category: Tnfr]]

Revision as of 21:03, 7 August 2013

Template:STRUCTURE 4kgg

Contents

Crystal structure of light mutant2 and dcr3 complex

Function

[TNF6B_HUMAN] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.[1] [TNF14_HUMAN] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.

About this Structure

4kgg is a 4 chain structure with sequence from Clostridium acetobutylicum and Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Zhan C, Patskovsky Y, Yan Q, Li Z, Ramagopal U, Cheng H, Brenowitz M, Hui X, Nathenson SG, Almo SC. Decoy Strategies: The Structure of TL1A:DcR3 Complex. Structure. 2011 Feb 9;19(2):162-71. PMID:21300286 doi:10.1016/j.str.2010.12.004

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OCA

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