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2g9c

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[[Image:2g9c.gif|left|200px]]<br /><applet load="2g9c" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2g9c.gif|left|200px]]
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caption="2g9c, resolution 1.70&Aring;" />
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'''Modified pyrimidines Specifically bind the purine riboswitch'''<br />
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{{Structure
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|PDB= 2g9c |SIZE=350|CAPTION= <scene name='initialview01'>2g9c</scene>, resolution 1.70&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE+ION'>NCO</scene> and <scene name='pdbligand=3AY:PYRIMIDINE-2,4,6-TRIAMINE'>3AY</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Modified pyrimidines Specifically bind the purine riboswitch'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2G9C is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=ACT:'>ACT</scene>, <scene name='pdbligand=NCO:'>NCO</scene> and <scene name='pdbligand=3AY:'>3AY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9C OCA].
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2G9C is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9C OCA].
==Reference==
==Reference==
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Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17076468 17076468]
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Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17076468 17076468]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Batey, R T.]]
[[Category: Batey, R T.]]
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[[Category: triaminopyrimidine]]
[[Category: triaminopyrimidine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:29:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:02:01 2008''

Revision as of 15:02, 20 March 2008

Image:2g9c.gif


PDB ID 2g9c

Drag the structure with the mouse to rotate
, resolution 1.70Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



Modified pyrimidines Specifically bind the purine riboswitch


Overview

The purine riboswitch is a genetic regulatory element found in the 5'-untranslated regions of Gram-positive bacteria that regulates expression of the mRNA specifically in response to either guanine or adenine. We report that the adenine-responsive RNA element is also capable of specifically recognizing pyrimidine compounds bearing modifications at the 6- or 5,6-positions in a fashion similar to that of purine compounds. Using isothermal titration calorimetry and X-ray crystallography, the binding of these compounds is characterized.

About this Structure

2G9C is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:17076468

Page seeded by OCA on Thu Mar 20 17:02:01 2008

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