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4ez1

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{{STRUCTURE_4ez1| PDB=4ez1 | SCENE= }}
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==Crystal structure of acetylcholine binding protein (AChBP) from Aplysia Californica in complex with alpha-conotoxin BuIA==
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===Crystal structure of acetylcholine binding protein (AChBP) from Aplysia Californica in complex with alpha-conotoxin BuIA===
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<StructureSection load='4ez1' size='340' side='right' caption='[[4ez1]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4ez1]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EZ1 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/CA1A_CONBU CA1A_CONBU]] Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This peptide potently blocks numerous mammalian nAChR subtypes (alpha-6 or -3/beta-2 or -3 > alpha-6 or-3/beta-4 > alpha-3/beta-2 > alpha-3/beta-4 > alpha-4/beta-4 = alpha-2/beta-4 > alpha-7 > alpha-2/beta-2 >> alpha-4/beta-2). Recovery from toxin block is markedly slower for beta-4 versus beta-2 subunit-containing nAChRs. Thus, it represents a novel probe for distinguishing between beta-2 and beta-4-containing nAChRs.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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==About this Structure==
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2i28|2i28]], [[2byp|2byp]], [[2c9t|2c9t]], [[2uz6|2uz6]], [[2br8|2br8]], [[2c79|2c79]], [[2c84|2c84]]</td></tr>
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[[4ez1]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZ1 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ez1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ez1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ez1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ez1 PDBsum]</span></td></tr>
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</table>
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__TOC__
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</StructureSection>
[[Category: Aplysia californica]]
[[Category: Aplysia californica]]
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[[Category: Ho, K.]]
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[[Category: Ho, K]]
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[[Category: Kim, C.]]
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[[Category: Kim, C]]
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[[Category: McIntosh, J M.]]
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[[Category: McIntosh, J M]]
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[[Category: Reger, A S.]]
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[[Category: Reger, A S]]
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[[Category: Sankaran, B.]]
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[[Category: Sankaran, B]]
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[[Category: Talley, T T.]]
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[[Category: Talley, T T]]
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[[Category: Taylor, P.]]
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[[Category: Taylor, P]]
[[Category: Choline binding protein-toxin complex]]
[[Category: Choline binding protein-toxin complex]]

Revision as of 11:49, 21 December 2014

Crystal structure of acetylcholine binding protein (AChBP) from Aplysia Californica in complex with alpha-conotoxin BuIA

4ez1, resolution 2.49Å

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