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4k37

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{{STRUCTURE_4k37| PDB=4k37 | SCENE= }}
{{STRUCTURE_4k37| PDB=4k37 | SCENE= }}
===Native anSMEcpe with bound AdoMet===
===Native anSMEcpe with bound AdoMet===
 +
{{ABSTRACT_PUBMED_23650368}}
==Function==
==Function==
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==Reference==
==Reference==
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<references group="xtra"/><references/>
+
<ref group="xtra">PMID:023650368</ref><references group="xtra"/><references/>
[[Category: Clostridium perfringens atcc 13124]]
[[Category: Clostridium perfringens atcc 13124]]
[[Category: Drennan, C L.]]
[[Category: Drennan, C L.]]

Revision as of 16:04, 19 June 2013

Template:STRUCTURE 4k37

Contents

Native anSMEcpe with bound AdoMet

Template:ABSTRACT PUBMED 23650368

Function

[ANSME_CLOP1] Involved in 'Cys-type' sulfatase maturation under anaerobic conditions. Catalyzes the post-translational modification of cysteine ('Cys-51' in the arylsulfatase CPF_0221) into 3-oxoalanine (also known as C(alpha)-formylglycine (FGly)), by a free radical chemical mechanism initiated via the reductive cleavage of S-adenosyl-L-methionine (SAM). Is also able to oxidize a serine residue in a synthetic substrate to FGly in vitro, and in a serine variant of a Cys-type sulfatase in vivo, but this activity is not physiological.[1] [2] [3]

About this Structure

4k37 is a 2 chain structure with sequence from Clostridium perfringens atcc 13124. Full crystallographic information is available from OCA.

Reference

  • Goldman PJ, Grove TL, Sites LA, McLaughlin MI, Booker SJ, Drennan CL. X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8519-24. doi:, 10.1073/pnas.1302417110. Epub 2013 May 6. PMID:23650368 doi:10.1073/pnas.1302417110
  1. ↑ Berteau O, Guillot A, Benjdia A, Rabot S. A new type of bacterial sulfatase reveals a novel maturation pathway in prokaryotes. J Biol Chem. 2006 Aug 11;281(32):22464-70. Epub 2006 Jun 9. PMID:16766528 doi:M602504200
  2. ↑ Benjdia A, Leprince J, Guillot A, Vaudry H, Rabot S, Berteau O. Anaerobic sulfatase-maturating enzymes: radical SAM enzymes able to catalyze in vitro sulfatase post-translational modification. J Am Chem Soc. 2007 Mar 28;129(12):3462-3. Epub 2007 Mar 3. PMID:17335281 doi:10.1021/ja067175e
  3. ↑ Benjdia A, Subramanian S, Leprince J, Vaudry H, Johnson MK, Berteau O. Anaerobic sulfatase-maturating enzymes, first dual substrate radical S-adenosylmethionine enzymes. J Biol Chem. 2008 Jun 27;283(26):17815-26. doi: 10.1074/jbc.M710074200. Epub 2008, Apr 11. PMID:18408004 doi:10.1074/jbc.M710074200

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