3qsv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{STRUCTURE_3qsv| PDB=3qsv | SCENE= }}
+
==Structural basis for DNA recognition by constitutive Smad4 MH1 dimers==
-
===Structural basis for DNA recognition by constitutive Smad4 MH1 dimers===
+
<StructureSection load='3qsv' size='340' side='right' caption='[[3qsv]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
-
{{ABSTRACT_PUBMED_021724602}}
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[3qsv]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QSV FirstGlance]. <br>
-
==Function==
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
[[http://www.uniprot.org/uniprot/SMAD4_MOUSE SMAD4_MOUSE]] Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).
+
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Smad4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qsv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qsv RCSB], [http://www.ebi.ac.uk/pdbsum/3qsv PDBsum]</span></td></tr>
-
==About this Structure==
+
</table>
-
[[3qsv]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QSV OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Baburajendran, N.]]
+
[[Category: Baburajendran, N]]
-
[[Category: Jauch, R.]]
+
[[Category: Jauch, R]]
-
[[Category: Kolatkar, P R.]]
+
[[Category: Kolatkar, P R]]
-
[[Category: Zhen, C T.Y.]]
+
[[Category: Zhen, C T.Y]]
[[Category: Dna binding]]
[[Category: Dna binding]]
[[Category: Mh1]]
[[Category: Mh1]]

Revision as of 10:14, 19 December 2014

Structural basis for DNA recognition by constitutive Smad4 MH1 dimers

3qsv, resolution 2.71Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3qsv"
Personal tools