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3aqz
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of Plodia interpunctella beta-GRP/GNBP3 N-terminal domain with laminarihexaoses== | |
| - | + | <StructureSection load='3aqz' size='340' side='right' caption='[[3aqz]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3aqz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plodia_interpunctella Plodia interpunctella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AQZ FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ie4|3ie4]], [[2rqe|2rqe]], [[2kha|2kha]], [[3aqx|3aqx]], [[3aqy|3aqy]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3aqz RCSB], [http://www.ebi.ac.uk/pdbsum/3aqz PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Innate ability to detect pathogens is achieved by pattern recognition receptors (PRRs) which recognise non-self components such as beta1,3-glucan. beta1,3-Glucans form a triple-helical structure stabilised by inter-chain hydrogen bonds. beta1,3-Glucan recognition protein (betaGRP)/gram-negative bacteria-binding protein 3 (GNBP3), one of PPRs, binds to long, structured beta1,3-glucan to initiate innate immune response. However, binding details and how specificity is achieved in such receptors remain important outstanding issues. We solved the crystal structures of the N-terminal beta1,3-glucan recognition domain of betaGRP/GNBP3 (betaGRP-N) in complex with the beta1,3-linked glucose hexamer, laminarihexaose. In the crystals, three structured laminarihexaoses simultaneously interact through six glucose residues (two from each chain) with one betaGRP-N. The spatial arrangement of the laminarihexaoses bound to betaGRP-N is almost identical to that of a beta1,3-glucan triplex. Therefore, our crystallographic structures together with site-directed mutagenesis data provide a structural basis for the unique recognition by such receptors of the triple-helix structure of beta1,3-glucan. | ||
| - | + | Structural insights into recognition of triple-helical {beta}-glucan by insect fungal receptor.,Kanagawa M, Satoh T, Ikeda A, Adachi Y, Ohno N, Yamaguchi Y J Biol Chem. 2011 Jun 22. PMID:21697086<ref>PMID:21697086</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Plodia interpunctella]] | [[Category: Plodia interpunctella]] | ||
| - | [[Category: Adachi, Y | + | [[Category: Adachi, Y]] |
| - | [[Category: Ikeda, A | + | [[Category: Ikeda, A]] |
| - | [[Category: Kanagawa, M | + | [[Category: Kanagawa, M]] |
| - | [[Category: Ohno, N | + | [[Category: Ohno, N]] |
| - | [[Category: Satoh, T | + | [[Category: Satoh, T]] |
| - | [[Category: Yamaguchi, Y | + | [[Category: Yamaguchi, Y]] |
[[Category: 3-glucan]] | [[Category: 3-glucan]] | ||
[[Category: Beta-1]] | [[Category: Beta-1]] | ||
Revision as of 14:13, 18 December 2014
Crystal structure of Plodia interpunctella beta-GRP/GNBP3 N-terminal domain with laminarihexaoses
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