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2kzy

From Proteopedia

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{{STRUCTURE_2kzy| PDB=2kzy | SCENE= }}
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==Solution NMR structure of the ZNF216 A20 zinc finger==
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===Solution NMR structure of the ZNF216 A20 zinc finger===
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<StructureSection load='2kzy' size='340' side='right' caption='[[2kzy]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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{{ABSTRACT_PUBMED_021923101}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kzy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZY FirstGlance]. <br>
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==Function==
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[http://www.uniprot.org/uniprot/B5DF11_RAT B5DF11_RAT]] Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation (By similarity).
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Zfand5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kzy RCSB], [http://www.ebi.ac.uk/pdbsum/2kzy PDBsum]</span></td></tr>
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==About this Structure==
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</table>
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[[2kzy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZY OCA].
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__TOC__
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</StructureSection>
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Garner, T P.]]
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[[Category: Garner, T P]]
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[[Category: Layfield, R.]]
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[[Category: Layfield, R]]
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[[Category: Long, J E.]]
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[[Category: Long, J E]]
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[[Category: Searle, M S.]]
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[[Category: Searle, M S]]
[[Category: A20 domain]]
[[Category: A20 domain]]
[[Category: Atrogene]]
[[Category: Atrogene]]

Revision as of 12:49, 18 December 2014

Solution NMR structure of the ZNF216 A20 zinc finger

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